(Z)-3-(1-Methyl-cyclopropylamino)-2-(2,3,4,5-tetrafluoro-benzoyl)-acrylic acid ethyl ester

Base Information

Chemical Name:(Z)-3-(1-Methyl-cyclopropylamino)-2-(2,3,4,5-tetrafluoro-benzoyl)-acrylic acid ethyl ester
CAS No.:113220-22-7
Molecular Formula:C₁₆H₁₅F₄NO₃
Molecular Weight:345.294
Hs Code.:

Synonyms:(Z)-3-(1-Methyl-cyclopropylamino)-2-(2,3,4,5-tetrafluoro-benzoyl)-acrylic acid ethyl ester

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Chemical Property of (Z)-3-(1-Methyl-cyclopropylamino)-2-(2,3,4,5-tetrafluoro-benzoyl)-acrylic acid ethyl ester

Chemical Property:

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Technology Process of (Z)-3-(1-Methyl-cyclopropylamino)-2-(2,3,4,5-tetrafluoro-benzoyl)-acrylic acid ethyl ester

There total 3 articles about (Z)-3-(1-Methyl-cyclopropylamino)-2-(2,3,4,5-tetrafluoro-benzoyl)-acrylic acid ethyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 94695-50-8
ethyl 3-(2,3,4,5-tetrafkuorophenyl)-3-oxopropanoate

: 122-51-0
orthoformic acid triethyl ester

: 88887-87-0
1-methylcyclopropylamine hydrochloride

: 113220-22-7
(Z)-3-(1-Methyl-cyclopropylamino)-2-(2,3,4,5-tetrafluoro-benzoyl)-acrylic acid ethyl ester

Guidance literature:: With acetic anhydride; Multistep reaction; 1.) 150 deg C, 2 h, 2.) t-BuOH, 10 deg C, 30 min; 45 deg C, overnoght;
DOI:10.1021/jm00400a017

Reference yield:

: 1201-31-6
2,3,4,5-tetrafluorobenzoic acid

: 113220-22-7
(Z)-3-(1-Methyl-cyclopropylamino)-2-(2,3,4,5-tetrafluoro-benzoyl)-acrylic acid ethyl ester

Guidance literature:: Multi-step reaction with 3 steps

1: (COCl)2, DMF / CH₂Cl₂

2: tetrahydrofuran / 0.75 h / -78 °C

3: 1.) Ac₂O / 1.) 150 deg C, 2 h, 2.) t-BuOH, 10 deg C, 30 min; 45 deg C, overnoght

With oxalyl dichloride; acetic anhydride; N,N-dimethyl-formamide; In tetrahydrofuran; dichloromethane;
DOI:10.1021/jm00400a017

Reference yield:

: 94695-48-4
2,3,4,5-tetrafluorobenzoyl chloride

: 113220-22-7
(Z)-3-(1-Methyl-cyclopropylamino)-2-(2,3,4,5-tetrafluoro-benzoyl)-acrylic acid ethyl ester

Guidance literature:: Multi-step reaction with 2 steps

1: tetrahydrofuran / 0.75 h / -78 °C

2: 1.) Ac₂O / 1.) 150 deg C, 2 h, 2.) t-BuOH, 10 deg C, 30 min; 45 deg C, overnoght

With acetic anhydride; In tetrahydrofuran;
DOI:10.1021/jm00400a017