1-Methylcyclopropylamine hydrochloride

Base Information

• Chemical Name: 1-Methylcyclopropylamine hydrochloride
• CAS No.: 88887-87-0
• Molecular Formula: C4H10ClN
• Molecular Weight: 107.583
• Hs Code.: 2921300090
• Mol file: 88887-87-0.mol

Synonyms:Cyclopropanamine,1-methyl-, hydrochloride (9CI);1-Methyl-1-cyclopropanamine hydrochloride;1-Methylcyclopropylamine hydrochloride;

Chemical Property of 1-Methylcyclopropylamine hydrochloride

Chemical Property:

• Vapor Pressure: 20.4mmHg at 25°C
• Melting Point: 204-205 °C(Solv: ethyl acetate (141-78-6); methanol (67-56-1))
• Boiling Point: 112 °C at 760 mmHg
• Flash Point: 21.5 °C
• PSA: 26.02000
• LogP: 1.99990
• Storage Temp.: under inert gas (nitrogen or Argon) at 2-8°C

Purity/Quality:

98%,99%, ^*data from raw suppliers

1-Methylcyclopropanaminehydrochloride ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 1-Methylcyclopropylamine hydrochloride

There total 6 articles about 1-Methylcyclopropylamine hydrochloride which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 92.0%

1,1-dimethylethyl (1-methylcyclopropyl)carbamate (251661-01-5) → 1-methylcyclopropylamine hydrochloride (88887-87-0)

Guidance literature:

With hydrogenchloride; In 1,4-dioxane; at 20 ℃;

Reference yield: 85.0%

1-Methyl-cyclopropanoic acid (6914-76-7) → 1-methylcyclopropylamine hydrochloride (88887-87-0)

Guidance literature:

1-Methyl-cyclopropanoic acid; With diphenyl phosphoryl azide; triethylamine; In tert-butyl alcohol; at 20 - 75 ℃; for 16h;

With hydrogenchloride; In 1,4-dioxane; water; for 3h;

Reference yield: 72.0%

N-(1-methylcyclopropyl)-N'-(tert-butoxycarbonyl)hydrazinecarboxylic acid tert-butyl ester + acetone (67-64-1) → isopropyl-(1-methyl-cyclopropyl)-amine; hydrochloride + 1-methylcyclopropylamine hydrochloride (88887-87-0)

Guidance literature:

N-(1-methylcyclopropyl)-N'-(tert-butoxycarbonyl)hydrazinecarboxylic acid tert-butyl ester; With hydrogenchloride; In tetrahydrofuran; for 1h;

acetone; With hydrogenchloride; acetic acid; zinc; for 2h;

DOI:10.1021/ja062355+

upstream raw materials:

1-Methyl-cyclopropanoic acid

acetone

1,1-dimethylethyl (1-methylcyclopropyl)carbamate

N-bromo-1-methylcyclopropanecarboxamide

Downstream raw materials:

4-fluoro-2-(4-fluorophenyl)-5-(4-methoxy-2-methyl-5-(1-methylcyclopropylcarbamoyl)phenyl)-N-methylpyrazolo[1,5-a]pyridine-3-carboxamide

Refernces

• 1、 Waszkowycz, Bohdan,Smith, Kate M.,McGonagle, Alison E.,Jordan, Allan M.,Acton, Ben,Fairweather, Emma E.,Griffiths, Louise A.,Hamilton, Niall M.,Hamilton, Nicola S.,Hitchin, James R.,Hutton, Colin P.,James, Dominic I.,Jones, Clifford D.,Jones, Stuart,Mould, Daniel P.,Small, Helen F.,Stowell, Alexandra I. J.,Tucker, Julie A.,Waddell, Ian D.,Ogilvie, Donald J.. "Cell-Active Small Molecule Inhibitors of the DNA-Damage Repair Enzyme Poly(ADP-ribose) Glycohydrolase (PARG): Discovery and Optimization of Orally Bioavailable Quinazolinedione Sulfonamides". supporting information. p. 10767 - 10792. Retrieved 2019/01/04.
• 2、 -. "PYRIMIDONE CARBOXAMIDE COMPOUNDS AS PDE2 INHIBITORS". Page/Page column 45; 46. . Retrieved 2015/07/15.