N-(2-{5-methoxy-1-[(4-methylphenyl)sulfonyl]-1H-indol-3-yl}ethyl)acetamide

Base Information

Chemical Name:N-(2-{5-methoxy-1-[(4-methylphenyl)sulfonyl]-1H-indol-3-yl}ethyl)acetamide
CAS No.:1020701-51-2
Molecular Formula:C₂₀H₂₂N₂O₄S
Molecular Weight:386.472
Hs Code.:

Synonyms:N-(2-{5-methoxy-1-[(4-methylphenyl)sulfonyl]-1H-indol-3-yl}ethyl)acetamide

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Chemical Property of N-(2-{5-methoxy-1-[(4-methylphenyl)sulfonyl]-1H-indol-3-yl}ethyl)acetamide

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Technology Process of N-(2-{5-methoxy-1-[(4-methylphenyl)sulfonyl]-1H-indol-3-yl}ethyl)acetamide

There total 5 articles about N-(2-{5-methoxy-1-[(4-methylphenyl)sulfonyl]-1H-indol-3-yl}ethyl)acetamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 90.5%

: 73-31-4
5-methoxy-N-acetyl-tryptamine

: 98-59-9
p-toluenesulfonyl chloride

: 1020701-51-2
N-(2-{5-methoxy-1-[(4-methylphenyl)sulfonyl]-1H-indol-3-yl}ethyl)acetamide

Guidance literature:: 5-methoxy-N-acetyl-tryptamine; With tetrabutylammomium bromide; sodium hydroxide; In dichloromethane; at 20 ℃; for 0.5h;

p-toluenesulfonyl chloride; In dichloromethane; at 20 ℃; for 6h;
DOI:10.1021/acs.orglett.8b03641

Reference yield:

: 10601-19-1
5-methoxyindole-3-carboxaldehyde

: 1020701-51-2
N-(2-{5-methoxy-1-[(4-methylphenyl)sulfonyl]-1H-indol-3-yl}ethyl)acetamide

Guidance literature:: Multi-step reaction with 4 steps

1.1: ammonium acetate / 1.5 h / Reflux; Inert atmosphere

2.1: lithium aluminium tetrahydride / tetrahydrofuran / 36 h / 0 - 20 °C / Inert atmosphere

3.1: sodium carbonate / water; dichloromethane / 2 h / Inert atmosphere

4.1: sodium hydroxide; tetra(n-butyl)ammonium hydrogensulfate / dichloromethane / 0.08 h / 20 °C / Inert atmosphere

4.2: 5 h / 20 °C / Inert atmosphere

With lithium aluminium tetrahydride; ammonium acetate; tetra(n-butyl)ammonium hydrogensulfate; sodium carbonate; sodium hydroxide; In tetrahydrofuran; dichloromethane; water;
DOI:10.1039/c7gc01341h

Reference yield:

: 61675-19-2
5-methoxy-3-(2-nitroethylenyl)-1H-indole

: 1020701-51-2
N-(2-{5-methoxy-1-[(4-methylphenyl)sulfonyl]-1H-indol-3-yl}ethyl)acetamide

Guidance literature:: Multi-step reaction with 3 steps

1.1: lithium aluminium tetrahydride / tetrahydrofuran / 36 h / 0 - 20 °C / Inert atmosphere

2.1: sodium carbonate / water; dichloromethane / 2 h / Inert atmosphere

3.1: sodium hydroxide; tetra(n-butyl)ammonium hydrogensulfate / dichloromethane / 0.08 h / 20 °C / Inert atmosphere

3.2: 5 h / 20 °C / Inert atmosphere

With lithium aluminium tetrahydride; tetra(n-butyl)ammonium hydrogensulfate; sodium carbonate; sodium hydroxide; In tetrahydrofuran; dichloromethane; water;
DOI:10.1039/c7gc01341h