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Melatonin

Base Information Edit
  • Chemical Name:Melatonin
  • CAS No.:73-31-4
  • Deprecated CAS:1581233-31-9
  • Molecular Formula:C13H16N2O2
  • Molecular Weight:232.282
  • Hs Code.:29379000
  • European Community (EC) Number:200-797-7
  • NSC Number:113928,56423
  • UNII:JL5DK93RCL
  • DSSTox Substance ID:DTXSID1022421
  • Nikkaji Number:J5.258B
  • Wikipedia:Melatonin
  • Wikidata:Q180912
  • NCI Thesaurus Code:C632
  • RXCUI:6711
  • Pharos Ligand ID:6Z25GWWZWN5K
  • Metabolomics Workbench ID:37767
  • ChEMBL ID:CHEMBL45
  • Mol file:73-31-4.mol
Melatonin

Synonyms:Melatonin

Suppliers and Price of Melatonin
Supply Marketing:Edit
Business phase:
The product has achieved commercial mass production*data from LookChem market partment
Manufacturers and distributors:
  • Manufacture/Brand
  • Chemicals and raw materials
  • Packaging
  • price
  • Usbiological
  • Melatonin
  • 96Tests
  • $ 1318.00
  • Usbiological
  • Melatonin
  • 1mg
  • $ 499.00
  • Usbiological
  • Melatonin
  • 48Tests
  • $ 588.00
  • Usbiological
  • Melatonin
  • 200ul
  • $ 581.00
  • Usbiological
  • Melatonin
  • 96Tests
  • $ 739.00
  • Usbiological
  • Melatonin
  • 96Tests
  • $ 739.00
  • Usbiological
  • Melatonin
  • 96Tests
  • $ 739.00
  • TRC
  • Melatonin
  • 1g
  • $ 60.00
  • Tocris
  • Melatonin ≥99%(HPLC)
  • 50
  • $ 75.00
  • TCI Chemical
  • Melatonin >98.0%(HPLC)(N)
  • 5g
  • $ 149.00
Total 332 raw suppliers
Chemical Property of Melatonin Edit
Chemical Property:
  • Appearance/Colour:Off-white powder 
  • Vapor Pressure:1.25E-10mmHg at 25°C 
  • Melting Point:116.5-118 °C(lit.) 
  • Refractive Index:1.6 
  • Boiling Point:512.831 °C at 760 mmHg 
  • PKA:16.26±0.46(Predicted) 
  • Flash Point:263.951 °C 
  • PSA:54.12000 
  • Density:1.175 g/cm3 
  • LogP:2.24600 
  • Storage Temp.:-15°C 
  • Solubility.:Soluble in ethanol to at least 50mg/ml 
  • XLogP3:0.8
  • Hydrogen Bond Donor Count:2
  • Hydrogen Bond Acceptor Count:2
  • Rotatable Bond Count:4
  • Exact Mass:232.121177757
  • Heavy Atom Count:17
  • Complexity:270
Purity/Quality:

99% *data from raw suppliers

Melatonin *data from reagent suppliers

Safty Information:
  • Pictogram(s): Toxic
  • Hazard Codes:T,F 
  • Statements: 60-39/23/24/25-23/24/25-11 
  • Safety Statements: 24/25-99-53-45-36/37-16-7 
MSDS Files:

SDS file from LookChem

Total 1 MSDS from other Authors

Useful:
  • Drug Classes:Herbals and Dietary Supplements
  • Canonical SMILES:CC(=O)NCCC1=CNC2=C1C=C(C=C2)OC
  • Recent ClinicalTrials:Melatonin as a Neuroprotective Therapy in Neonates With HIE Undergoing Hypothermia
  • Recent EU Clinical Trials:MELAtonin for prevention of Postoperative Agitation and Emergence Delirium in children. The MELA-PAED trial: a randomized, double-blind, placebo-controlled clinical trial.
  • Recent NIPH Clinical Trials:Can ramelteon decrease the tic of Tourette's syndrome
  • description Melatonin is a hormone secreted by the pineal gland, and its chemical structure was 5-methoxy-N-acetyl tryptamine, the physiological function of inhibiting gonad, thyroid, adrenal gland, parathyroid gland and pituitary function, inhibit precocious puberty, reduce pituitary Melanotropin secretion; and has a central nervous system function, can improve the convulsion the threshold, cause drowsiness. When pinealectomy after the animal experiment showed hyperplasia of the glands, weight increase, especially sex and sexual organs of immature rats early, pituitary secretion of LH and FSH increased, increasing secretion of thyroid and adrenal cortex hormone melatonin. More reduced pituitary MSH and whiten the skin of this role. Effects on the central nervous system, in the human EEG showed slow rhythm, increased seizure threshold, sleepiness, but does not affect their behavior and personality, of temporal lobe epilepsy and Ba Jinsen disease can reduce the motor nerve Abnormal EEG changes.
  • Uses 1. Melatonin can be used as medicine health care products, so as to enhance people’s immune function, preventing aging and back to youth. What’s more, it is also a kind of natural “sleeping pill”. 2. Melatonin is a kind of hormone secreted by pineal body of pituitary gland in the body. The amount of melatonin has something to do with light. The weaker the light is, the more the melatonin is, whereas the less. In addition, it is helpful to one’s sleep. 3. Biochemical research. Melatonine can be used in sleep induction, modifies circadian rhythm, antioxidant, free radical scavenger Immunostimulant;Melatonin receptor ligand Melatonin has complex effects on apoptotic pathways, inhibiting apoptosis in immune cells and neurons but enhancing apoptotic cell death of cancer cells. Inhibits proliferation/metastasis of breast cancer cells by inhibiting estrogen receptor action.
  • Description Melatonin, at times referred to as the “hormone of darkness,” normally is secreted during the night. It is synthesized in the pineal gland, and its secretion is controlled by the suprachiasmatic nucleus, following an endogenous circadian rhythm. Studies indicate that melatonin may
  • Clinical Use Melatonin is most effective in young individuals and appears to be less effective in elderly individuals (possibly because of a decreased number of receptors). Melatonin causes a phase shift of approximately 1 hour per day. This means that the use of melatonin in the morning can delay the onset of evening sleepiness, whereas melatonin taken in the evening has been associated with faster onset of sleep and increased total sleep time. Melatonin is sold as a food supplement in the United States, but it has become popular for use as a hypnotic and for alleviating jet lag (a flight across five or more time zones) and helping to resynchronize individuals who have difficulty adapting to night-shift work. have effects on circadian rhythm and sleep processes. The presence of a pharmacologically specific receptor for melatonin in which the molecular structure is known are referred to as MT1, MT2, and MT3 receptors. The MT1 and MT2 receptors are high-affinity G protein coupled receptors, whereas MT3 is a form of quinone reductase. The MT1 receptor appears to be primarily involved in initiating sleep, whereas the MT2 receptor appears to mediate melatonins effect in the eye, circadian rhythm, and vascular effects. The importance of MT3, although widely distributed in different tissues, is currently unknown. The normal physiological concentration of melatonin observed at night is approximately 100 to 200 pg/mL, and oral doses of 0.1 to 0.3 mg of melatonin are adequate to obtain these concentrations even though melatonin frequently is given at doses of 1 to 10 mg to obtain supraphysiological levels. These higher doses may be the reason for some of the side effects not currently associated with the melatonin receptors.
Technology Process of Melatonin

There total 76 articles about Melatonin which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:
Guidance literature:
With pyridine; In dichloromethane;
DOI:10.1016/j.tet.2016.08.014
Guidance literature:
In dichloromethane; at 25 - 30 ℃; Temperature;
Guidance literature:
With tetrabutylammonium tetrafluoroborate; In ethyl acetate; at 20 ℃; Electrochemical reaction;
DOI:10.1002/cssc.201900814
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