(4S,5R)-2-(6-tert-butyl-4-ethoxy-pyridin-3-yl)-4,5-bis-(4-chloro-phenyl)-4,5-dimethyl-4,5-dihydro-innidazole-1-carbonyl chloride

Base Information

Chemical Name:(4S,5R)-2-(6-tert-butyl-4-ethoxy-pyridin-3-yl)-4,5-bis-(4-chloro-phenyl)-4,5-dimethyl-4,5-dihydro-innidazole-1-carbonyl chloride
CAS No.:1143519-95-2
Molecular Formula:C₂₉H₃₀Cl₃N₃O₂
Molecular Weight:558.935
Hs Code.:

Synonyms:

Suppliers and Price of (4S,5R)-2-(6-tert-butyl-4-ethoxy-pyridin-3-yl)-4,5-bis-(4-chloro-phenyl)-4,5-dimethyl-4,5-dihydro-innidazole-1-carbonyl chloride

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 0 raw suppliers

Chemical Property of (4S,5R)-2-(6-tert-butyl-4-ethoxy-pyridin-3-yl)-4,5-bis-(4-chloro-phenyl)-4,5-dimethyl-4,5-dihydro-innidazole-1-carbonyl chloride

Chemical Property:

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Technology Process of (4S,5R)-2-(6-tert-butyl-4-ethoxy-pyridin-3-yl)-4,5-bis-(4-chloro-phenyl)-4,5-dimethyl-4,5-dihydro-innidazole-1-carbonyl chloride

There total 7 articles about (4S,5R)-2-(6-tert-butyl-4-ethoxy-pyridin-3-yl)-4,5-bis-(4-chloro-phenyl)-4,5-dimethyl-4,5-dihydro-innidazole-1-carbonyl chloride which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 134653-81-9
ethyl 6-tert-butyl-4-oxo-4H-pyran-3-carboxylate

: 1143519-95-2
(4S,5R)-2-(6-tert-butyl-4-ethoxy-pyridin-3-yl)-4,5-bis-(4-chloro-phenyl)-4,5-dimethyl-4,5-dihydro-innidazole-1-carbonyl chloride

Guidance literature:: Multi-step reaction with 8 steps

1.1: ammonium acetate; acetic acid / ethanol; water / 0.5 h / 95 °C

2.1: potassium carbonate / N,N-dimethyl-formamide / 20 °C

3.1: potassium hydroxide; water / ethanol / 1 h / 80 °C

4.1: thionyl chloride / 2 h / 70 °C

5.1: N-ethyl-N,N-diisopropylamine / tetrahydrofuran / 0.83 h / -10 °C

6.1: trichlorophosphate / toluene / Heating / reflux

6.2: 0 °C

7.1: triethylamine / dichloromethane; toluene / 0.5 h / 0 °C

8.1: Resolution of racemate

With potassium hydroxide; thionyl chloride; ammonium acetate; water; potassium carbonate; acetic acid; triethylamine; N-ethyl-N,N-diisopropylamine; trichlorophosphate; In tetrahydrofuran; ethanol; dichloromethane; water; N,N-dimethyl-formamide; toluene;

Reference yield:

: 1143519-21-4
6-tert-butyl-4-ethoxy-nicotinic acid

: 1143519-95-2
(4S,5R)-2-(6-tert-butyl-4-ethoxy-pyridin-3-yl)-4,5-bis-(4-chloro-phenyl)-4,5-dimethyl-4,5-dihydro-innidazole-1-carbonyl chloride

Guidance literature:: Multi-step reaction with 5 steps

1.1: thionyl chloride / 2 h / 70 °C

2.1: N-ethyl-N,N-diisopropylamine / tetrahydrofuran / 0.83 h / -10 °C

3.1: trichlorophosphate / toluene / Heating / reflux

3.2: 0 °C

4.1: triethylamine / dichloromethane; toluene / 0.5 h / 0 °C

5.1: Resolution of racemate

With thionyl chloride; triethylamine; N-ethyl-N,N-diisopropylamine; trichlorophosphate; In tetrahydrofuran; dichloromethane; toluene;

Reference yield:

: 1143519-22-5
6-tert-butyl-4-ethoxy-nicotinoyl chloride

: 1143519-95-2
(4S,5R)-2-(6-tert-butyl-4-ethoxy-pyridin-3-yl)-4,5-bis-(4-chloro-phenyl)-4,5-dimethyl-4,5-dihydro-innidazole-1-carbonyl chloride

Guidance literature:: Multi-step reaction with 4 steps

1.1: N-ethyl-N,N-diisopropylamine / tetrahydrofuran / 0.83 h / -10 °C

2.1: trichlorophosphate / toluene / Heating / reflux

2.2: 0 °C

3.1: triethylamine / dichloromethane; toluene / 0.5 h / 0 °C

4.1: Resolution of racemate

With triethylamine; N-ethyl-N,N-diisopropylamine; trichlorophosphate; In tetrahydrofuran; dichloromethane; toluene;