Ticlid

Base Information

• Chemical Name: Ticlid
• CAS No.: 53885-35-1
• Molecular Formula: C14H14ClNS^.HCl
• Molecular Weight: 300.252
• Hs Code.: 2934990002
• Metabolomics Workbench ID: 53483
• Mol file: 53885-35-1.mol

Synonyms:53 32C;53-32C;5332C;Hydrochloride, Ticlopidine;Ticlid;Ticlodix;Ticlodone;Ticlopidine;Ticlopidine Hydrochloride

Chemical Property of Ticlid

Chemical Property:

• Appearance/Colour: White powder
• Vapor Pressure: 1.38E-05mmHg at 25°C
• Melting Point: 205°C
• Boiling Point: 367.3 °C at 760 mmHg
• PKA: 7.64(at 25℃)
• Flash Point: 175.9 °C
• PSA: 31.48000
• Density: 1.37 g/cm3
• LogP: 4.69970
• Storage Temp.: Desiccate at RT
• Solubility.: Sparingly soluble in water and in anhydrous ethanol, very slightly soluble in ethyl acetate.
• Water Solubility.: Soluble to 100 mM in water and to 100 mM in DMSO.
• Hydrogen Bond Donor Count: 1
• Hydrogen Bond Acceptor Count: 3
• Rotatable Bond Count: 2
• Exact Mass: 299.0302260
• Heavy Atom Count: 18
• Complexity: 261

Purity/Quality:

99% ^*data from raw suppliers

Ticlopidine, Hydrochloride ^*data from reagent suppliers

Safty Information:

• Pictogram(s): Xn
• Hazard Codes: Xn,Xi
• Statements: 22-36/37/38
• Safety Statements: 36-37/39-26

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: [H+].C1CN(CC2=C1SC=C2)CC3=CC=CC=C3Cl.[Cl-]
• Uses: Ticlopidine hydrochloride is a selective P2Y12 receptor antagonist. It inhibits ADP-induced platelet aggregation and displays antithrombotic activity following oral administration in vivo. An antithrombotic. a platelet aggregation inhibitor mucolytic, antibacterial, surface active agent
• Therapeutic Function: Platelet aggregation inhibitor

Technology Process of Ticlid

There total 16 articles about Ticlid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 95.0%

N-(2-chloro-benzyl)-2-(thien-2-yl)-ethylamine hydrochloride (60612-23-9) → ticlopidine hydrochloride (53885-35-1)

Guidance literature:

In 1,3-DIOXOLANE; ethyl acetate;

Reference yield: 90.0%

→ ticlopidine hydrochloride (53885-35-1)

Guidance literature:

Reference yield: 89.0%

1,3-DIOXOLANE (646-06-0) + N-(2-chloro-benzyl)-2-(thien-2-yl)-ethylamine hydrochloride (60612-23-9) → ticlopidine hydrochloride (53885-35-1)

Guidance literature:

With hydrogenchloride;

DOI:10.1248/cpb.42.1676

upstream raw materials:

1,3-DIOXOLANE

N-(2-chloro-benzyl)-2-(thien-2-yl)-ethylamine hydrochloride

1,3 dithiane

4,5,6,7-tetrahydrothieno[3,2-c]pyridine