3-(2-(4-cyano-2-methylphenyl)-3-(4-methoxyphenyl)-1H-pyrrol-1-yl)butanoic acid

Base Information

Chemical Name:3-(2-(4-cyano-2-methylphenyl)-3-(4-methoxyphenyl)-1H-pyrrol-1-yl)butanoic acid
CAS No.:1208330-73-7
Molecular Formula:C₂₃H₂₂N₂O₃
Molecular Weight:374.439
Hs Code.:

Synonyms:3-(2-(4-cyano-2-methylphenyl)-3-(4-methoxyphenyl)-1H-pyrrol-1-yl)butanoic acid

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of 3-(2-(4-cyano-2-methylphenyl)-3-(4-methoxyphenyl)-1H-pyrrol-1-yl)butanoic acid

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Technology Process of 3-(2-(4-cyano-2-methylphenyl)-3-(4-methoxyphenyl)-1H-pyrrol-1-yl)butanoic acid

There total 9 articles about 3-(2-(4-cyano-2-methylphenyl)-3-(4-methoxyphenyl)-1H-pyrrol-1-yl)butanoic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 99548-55-7
4-bromo-2-methyl-benzoic acid methyl ester

: 1208330-73-7
3-(2-(4-cyano-2-methylphenyl)-3-(4-methoxyphenyl)-1H-pyrrol-1-yl)butanoic acid

Guidance literature:: Multi-step reaction with 8 steps

1.1: N,N-dimethyl-formamide / 8 h / Reflux

2.1: water; sodium hydroxide / ethanol / 12 h / 20 °C

3.1: thionyl chloride; N,N-dimethyl-formamide / toluene / 14 h / 70 °C

4.1: lithium hexamethyldisilazane / tetrahydrofuran / 0.25 h / -78 °C / Inert atmosphere

4.2: -78 - 20 °C / Inert atmosphere

5.1: water; dimethyl sulfoxide / 2.5 h / 150 °C

6.1: lithium hexamethyldisilazane / tetrahydrofuran / 0.5 h / -78 °C / Inert atmosphere

6.2: -78 - 20 °C / Inert atmosphere

7.1: ozone / dichloromethane / 0.67 h / -78 °C

7.2: -78 - 20 °C

8.1: pyridinium p-toluenesulfonate / ethanol / 2 h / 60 °C

With thionyl chloride; water; pyridinium p-toluenesulfonate; ozone; N,N-dimethyl-formamide; sodium hydroxide; lithium hexamethyldisilazane; In tetrahydrofuran; ethanol; dichloromethane; water; dimethyl sulfoxide; N,N-dimethyl-formamide; toluene;
DOI:10.1016/j.bmcl.2011.04.086

Reference yield:

: 2835-82-7
3-aminobutyric acid

: 1208331-37-6
4-(2-(4-methoxyphenyl)-4-oxobutanoyl)-3-methylbenzonitrile

: 1208330-73-7
3-(2-(4-cyano-2-methylphenyl)-3-(4-methoxyphenyl)-1H-pyrrol-1-yl)butanoic acid

Guidance literature:: With pyridinium p-toluenesulfonate; In ethanol; at 60 ℃; for 2h;
DOI:10.1016/j.bmcl.2011.04.086

Reference yield:

: 1208331-31-0
ethyl 3-(4-cyano-2-methylphenyl)-2-(4-methoxyphenyl)-3-oxopropanoate

: 1208330-73-7
3-(2-(4-cyano-2-methylphenyl)-3-(4-methoxyphenyl)-1H-pyrrol-1-yl)butanoic acid

Guidance literature:: Multi-step reaction with 4 steps

1.1: water; dimethyl sulfoxide / 2.5 h / 150 °C

2.1: lithium hexamethyldisilazane / tetrahydrofuran / 0.5 h / -78 °C / Inert atmosphere

2.2: -78 - 20 °C / Inert atmosphere

3.1: ozone / dichloromethane / 0.67 h / -78 °C

3.2: -78 - 20 °C

4.1: pyridinium p-toluenesulfonate / ethanol / 2 h / 60 °C

With pyridinium p-toluenesulfonate; ozone; lithium hexamethyldisilazane; In tetrahydrofuran; ethanol; dichloromethane; water; dimethyl sulfoxide;
DOI:10.1016/j.bmcl.2011.04.086