tert-butyl 4-(4-(ethoxycarbonyl)phenyl)-4-fluoropiperidine-1-carboxylate

Base Information

Chemical Name:tert-butyl 4-(4-(ethoxycarbonyl)phenyl)-4-fluoropiperidine-1-carboxylate
CAS No.:1622205-32-6
Molecular Formula:C₁₉H₂₆FNO₄
Molecular Weight:351.418
Hs Code.:

Synonyms:tert-butyl 4-(4-(ethoxycarbonyl)phenyl)-4-fluoropiperidine-1-carboxylate

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Chemical Property of tert-butyl 4-(4-(ethoxycarbonyl)phenyl)-4-fluoropiperidine-1-carboxylate

Chemical Property:

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Technology Process of tert-butyl 4-(4-(ethoxycarbonyl)phenyl)-4-fluoropiperidine-1-carboxylate

There total 6 articles about tert-butyl 4-(4-(ethoxycarbonyl)phenyl)-4-fluoropiperidine-1-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 24424-99-5
di-tert-butyl dicarbonate

: 1622206-00-1
C₁₄H₁₈FNO₂

: 1622205-32-6
tert-butyl 4-(4-(ethoxycarbonyl)phenyl)-4-fluoropiperidine-1-carboxylate

Guidance literature:: With triethylamine; In dichloromethane; at 20 ℃; for 1h;

Reference yield:

: 32664-14-5
2-(4-bromophenyl)-4,4-dimethyl-2-oxazoline

: 1622205-32-6
tert-butyl 4-(4-(ethoxycarbonyl)phenyl)-4-fluoropiperidine-1-carboxylate

Guidance literature:: Multi-step reaction with 5 steps

1.1: magnesium; iodine / tetrahydrofuran / 1 h / Reflux

1.2: 3 h / 20 °C / Reflux

2.1: sulfuric acid / 12 h / 90 °C

3.1: diethylamino-sulfur trifluoride / dichloromethane / 3 h / -78 - 20 °C / Inert atmosphere

4.1: carbonochloridic acid 1-chloro-ethyl ester / dichloromethane / 2 h / 20 °C / Inert atmosphere

5.1: triethylamine / dichloromethane / 1 h / 20 °C

With carbonochloridic acid 1-chloro-ethyl ester; diethylamino-sulfur trifluoride; sulfuric acid; iodine; magnesium; triethylamine; In tetrahydrofuran; dichloromethane;

Reference yield:

: 3612-20-2
1-phenylmethyl-4-piperidone

: 1622205-32-6
tert-butyl 4-(4-(ethoxycarbonyl)phenyl)-4-fluoropiperidine-1-carboxylate

Guidance literature:: Multi-step reaction with 5 steps

1.1: magnesium; iodine / tetrahydrofuran / 1 h / Reflux

1.2: 3 h / 20 °C / Reflux

2.1: sulfuric acid / 12 h / 90 °C

3.1: diethylamino-sulfur trifluoride / dichloromethane / 3 h / -78 - 20 °C / Inert atmosphere

4.1: carbonochloridic acid 1-chloro-ethyl ester / dichloromethane / 2 h / 20 °C / Inert atmosphere

5.1: triethylamine / dichloromethane / 1 h / 20 °C

With carbonochloridic acid 1-chloro-ethyl ester; diethylamino-sulfur trifluoride; sulfuric acid; iodine; magnesium; triethylamine; In tetrahydrofuran; dichloromethane;