1-benzyl-4-(4-(4,4-dimethyl-4,5-dihydrooxazol-2-yl)phenyl)piperidin-4-ol

Base Information

Chemical Name:1-benzyl-4-(4-(4,4-dimethyl-4,5-dihydrooxazol-2-yl)phenyl)piperidin-4-ol
CAS No.:912947-38-7
Molecular Formula:C₂₃H₂₈N₂O₂
Molecular Weight:364.488
Hs Code.:

Synonyms:1-benzyl-4-(4-(4,4-dimethyl-4,5-dihydrooxazol-2-yl)phenyl)piperidin-4-ol

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Chemical Property of 1-benzyl-4-(4-(4,4-dimethyl-4,5-dihydrooxazol-2-yl)phenyl)piperidin-4-ol

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Technology Process of 1-benzyl-4-(4-(4,4-dimethyl-4,5-dihydrooxazol-2-yl)phenyl)piperidin-4-ol

There total 1 articles about 1-benzyl-4-(4-(4,4-dimethyl-4,5-dihydrooxazol-2-yl)phenyl)piperidin-4-ol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 35.0%

: 32664-14-5
2-(4-bromophenyl)-4,4-dimethyl-2-oxazoline

: 3612-20-2
1-phenylmethyl-4-piperidone

: 912947-38-7
1-benzyl-4-(4-(4,4-dimethyl-4,5-dihydrooxazol-2-yl)phenyl)piperidin-4-ol

Guidance literature:: 2-(4-bromophenyl)-4,4-dimethyl-2-oxazoline; With iodine; magnesium; In tetrahydrofuran; for 1h; Reflux;

1-phenylmethyl-4-piperidone; In tetrahydrofuran; at 20 ℃; for 3h; Reflux;

Reference yield: 58.0%

: 64-17-5
ethanol

: 912947-38-7
1-benzyl-4-(4-(4,4-dimethyl-4,5-dihydrooxazol-2-yl)phenyl)piperidin-4-ol

: 912947-39-8
ethyl 4-(1-benzyl-4-hydroxypiperidin-4-yl)benzoate

Guidance literature:: With sulfuric acid; at 90 ℃; for 12h;

Reference yield:

: 912947-38-7
1-benzyl-4-(4-(4,4-dimethyl-4,5-dihydrooxazol-2-yl)phenyl)piperidin-4-ol

: 1622205-32-6
tert-butyl 4-(4-(ethoxycarbonyl)phenyl)-4-fluoropiperidine-1-carboxylate

Guidance literature:: Multi-step reaction with 4 steps

1: sulfuric acid / 12 h / 90 °C

2: diethylamino-sulfur trifluoride / dichloromethane / 3 h / -78 - 20 °C / Inert atmosphere

3: carbonochloridic acid 1-chloro-ethyl ester / dichloromethane / 2 h / 20 °C / Inert atmosphere

4: triethylamine / dichloromethane / 1 h / 20 °C

With carbonochloridic acid 1-chloro-ethyl ester; diethylamino-sulfur trifluoride; sulfuric acid; triethylamine; In dichloromethane;