(R)-3-[(R)-Benzyloxy-((R)-2,2-diethyl-[1,3]dioxolan-4-yl)-methyl]-2-ethoxy-5-trimethylsilanyl-pent-1-en-4-yn-3-ol

Base Information

Chemical Name:(R)-3-[(R)-Benzyloxy-((R)-2,2-diethyl-[1,3]dioxolan-4-yl)-methyl]-2-ethoxy-5-trimethylsilanyl-pent-1-en-4-yn-3-ol
CAS No.:164215-27-4
Molecular Formula:C₂₅H₃₈O₅Si
Molecular Weight:446.659
Hs Code.:

Synonyms:(R)-3-[(R)-Benzyloxy-((R)-2,2-diethyl-[1,3]dioxolan-4-yl)-methyl]-2-ethoxy-5-trimethylsilanyl-pent-1-en-4-yn-3-ol

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Chemical Property of (R)-3-[(R)-Benzyloxy-((R)-2,2-diethyl-[1,3]dioxolan-4-yl)-methyl]-2-ethoxy-5-trimethylsilanyl-pent-1-en-4-yn-3-ol

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Technology Process of (R)-3-[(R)-Benzyloxy-((R)-2,2-diethyl-[1,3]dioxolan-4-yl)-methyl]-2-ethoxy-5-trimethylsilanyl-pent-1-en-4-yn-3-ol

There total 4 articles about (R)-3-[(R)-Benzyloxy-((R)-2,2-diethyl-[1,3]dioxolan-4-yl)-methyl]-2-ethoxy-5-trimethylsilanyl-pent-1-en-4-yn-3-ol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 84.0%

: 61210-52-4
(trimethylsilyl)ethynylmagnesium bromide

: 171189-77-8
(R)-1-Benzyloxy-1-((R)-2,2-diethyl-[1,3]dioxolan-4-yl)-3-ethoxy-but-3-en-2-one

: 164215-27-4
(R)-3-[(R)-Benzyloxy-((R)-2,2-diethyl-[1,3]dioxolan-4-yl)-methyl]-2-ethoxy-5-trimethylsilanyl-pent-1-en-4-yn-3-ol

Guidance literature:: In tetrahydrofuran;
DOI:10.1021/ja00102a074

Reference yield:

: 25636-49-1
3,3-dimethoxypentane

: 164215-27-4
(R)-3-[(R)-Benzyloxy-((R)-2,2-diethyl-[1,3]dioxolan-4-yl)-methyl]-2-ethoxy-5-trimethylsilanyl-pent-1-en-4-yn-3-ol

Guidance literature:: Multi-step reaction with 4 steps

1: 90 percent / p-TsOH / tetrahydrofuran / 4 h / Heating

2: 1.) NaH / 1.) THF, 0 deg C, 30 min, 2.) THF, a) 0 deg C, 15 min, b) 23 deg C, 3 h

3: tetrahydrofuran / 0.17 h / -78 °C

4: 84 percent / tetrahydrofuran; diethyl ether / 0.25 h / 0 °C

With sodium hydride; toluene-4-sulfonic acid; In tetrahydrofuran; diethyl ether;
DOI:10.1021/ja00136a008

Reference yield:

: 164215-26-3
(R)-2-Benzyloxy-2-((R)-2,2-diethyl-[1,3]dioxolan-4-yl)-N,N-dimethyl-acetamide

: 164215-27-4
(R)-3-[(R)-Benzyloxy-((R)-2,2-diethyl-[1,3]dioxolan-4-yl)-methyl]-2-ethoxy-5-trimethylsilanyl-pent-1-en-4-yn-3-ol

Guidance literature:: Multi-step reaction with 2 steps

1: tetrahydrofuran / 0.17 h / -78 °C

2: 84 percent / tetrahydrofuran; diethyl ether / 0.25 h / 0 °C

In tetrahydrofuran; diethyl ether;
DOI:10.1021/ja00136a008