(R)-4-[(1R,2S)-1-Benzyloxy-2-(tert-butyl-dimethyl-silanyloxymethyl)-2-trimethylsilanyloxy-but-3-ynyl]-2,2-diethyl-[1,3]dioxolane

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Chemical Name:(R)-4-[(1R,2S)-1-Benzyloxy-2-(tert-butyl-dimethyl-silanyloxymethyl)-2-trimethylsilanyloxy-but-3-ynyl]-2,2-diethyl-[1,3]dioxolane
CAS No.:164215-30-9
Molecular Formula:C₂₈H₄₈O₅Si₂
Molecular Weight:520.857
Hs Code.:

Synonyms:(R)-4-[(1R,2S)-1-Benzyloxy-2-(tert-butyl-dimethyl-silanyloxymethyl)-2-trimethylsilanyloxy-but-3-ynyl]-2,2-diethyl-[1,3]dioxolane

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Chemical Property of (R)-4-[(1R,2S)-1-Benzyloxy-2-(tert-butyl-dimethyl-silanyloxymethyl)-2-trimethylsilanyloxy-but-3-ynyl]-2,2-diethyl-[1,3]dioxolane

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Technology Process of (R)-4-[(1R,2S)-1-Benzyloxy-2-(tert-butyl-dimethyl-silanyloxymethyl)-2-trimethylsilanyloxy-but-3-ynyl]-2,2-diethyl-[1,3]dioxolane

There total 9 articles about (R)-4-[(1R,2S)-1-Benzyloxy-2-(tert-butyl-dimethyl-silanyloxymethyl)-2-trimethylsilanyloxy-but-3-ynyl]-2,2-diethyl-[1,3]dioxolane which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 75-77-4
chloro-trimethyl-silane

: (1R,2S)-1-Benzyloxy-2-(tert-butyl-dimethyl-silanyloxymethyl)-1-((R)-2,2-diethyl-[1,3]dioxolan-4-yl)-but-3-yn-2-ol

: 164215-30-9
(R)-4-[(1R,2S)-1-Benzyloxy-2-(tert-butyl-dimethyl-silanyloxymethyl)-2-trimethylsilanyloxy-but-3-ynyl]-2,2-diethyl-[1,3]dioxolane

Guidance literature:: With triethylamine; In dichloromethane; Yield given;
DOI:10.1021/ja00102a074

Reference yield:

: 25636-49-1
3,3-dimethoxypentane

: 164215-30-9
(R)-4-[(1R,2S)-1-Benzyloxy-2-(tert-butyl-dimethyl-silanyloxymethyl)-2-trimethylsilanyloxy-but-3-ynyl]-2,2-diethyl-[1,3]dioxolane

Guidance literature:: Multi-step reaction with 9 steps

1: 90 percent / p-TsOH / tetrahydrofuran / 4 h / Heating

2: 1.) NaH / 1.) THF, 0 deg C, 30 min, 2.) THF, a) 0 deg C, 15 min, b) 23 deg C, 3 h

3: tetrahydrofuran / 0.17 h / -78 °C

4: 84 percent / tetrahydrofuran; diethyl ether / 0.25 h / 0 °C

5: 1.) O₃, 2.) PPh₃ / 1.) CH₂Cl₂, EtOH, -78 deg C, 2.5 h, 2.) CH₂Cl₂, EtOH, from -78 to 23 deg C

6: NaBH₄ / methanol / 2 h / 0 - 23 °C

7: 78 percent / methanolic K₂CO₃ / 8 h / 23 °C

8: Et₃N, 4-DMAP / CH₂Cl₂ / 12 h / 23 °C

9: Et₃N, 4-DMAP / CH₂Cl₂ / 0.5 h / 23 °C

With dmap; sodium tetrahydroborate; sodium hydride; potassium carbonate; toluene-4-sulfonic acid; ozone; triethylamine; triphenylphosphine; In tetrahydrofuran; methanol; diethyl ether; dichloromethane;
DOI:10.1021/ja00136a008

Reference yield:

: 164215-29-6
(S)-2-[(R)-Benzyloxy-((R)-2,2-diethyl-[1,3]dioxolan-4-yl)-methyl]-but-3-yne-1,2-diol

: 164215-30-9
(R)-4-[(1R,2S)-1-Benzyloxy-2-(tert-butyl-dimethyl-silanyloxymethyl)-2-trimethylsilanyloxy-but-3-ynyl]-2,2-diethyl-[1,3]dioxolane

Guidance literature:: Multi-step reaction with 2 steps

1: Et₃N, 4-DMAP / CH₂Cl₂ / 12 h / 23 °C

2: Et₃N, 4-DMAP / CH₂Cl₂ / 0.5 h / 23 °C

With dmap; triethylamine; In dichloromethane;
DOI:10.1021/ja00136a008