N-{5-[5-trifluoromethyl-5-(3,5-dichlorophenyl)-4,5-dihydroisoxazol-3-yl]-2,3-dihydro-1H-inden-1-yl}propionamide

Base Information

Chemical Name:N-{5-[5-trifluoromethyl-5-(3,5-dichlorophenyl)-4,5-dihydroisoxazol-3-yl]-2,3-dihydro-1H-inden-1-yl}propionamide
CAS No.:1118626-07-5
Molecular Formula:C₂₂H₁₉Cl₂F₃N₂O₂
Molecular Weight:471.306
Hs Code.:

Synonyms:N-{5-[5-trifluoromethyl-5-(3,5-dichlorophenyl)-4,5-dihydroisoxazol-3-yl]-2,3-dihydro-1H-inden-1-yl}propionamide

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Chemical Property of N-{5-[5-trifluoromethyl-5-(3,5-dichlorophenyl)-4,5-dihydroisoxazol-3-yl]-2,3-dihydro-1H-inden-1-yl}propionamide

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Technology Process of N-{5-[5-trifluoromethyl-5-(3,5-dichlorophenyl)-4,5-dihydroisoxazol-3-yl]-2,3-dihydro-1H-inden-1-yl}propionamide

There total 6 articles about N-{5-[5-trifluoromethyl-5-(3,5-dichlorophenyl)-4,5-dihydroisoxazol-3-yl]-2,3-dihydro-1H-inden-1-yl}propionamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

: N-{5-[ 3-(3,5-dichlorophenyl)-4,4,4-trifluoro-but-2-enoyl]-2,3-dihydro-1H-inden-1-yl}propionamide

: 1118626-07-5
N-{5-[5-trifluoromethyl-5-(3,5-dichlorophenyl)-4,5-dihydroisoxazol-3-yl]-2,3-dihydro-1H-inden-1-yl}propionamide

Guidance literature:: N-{5-[ 3-(3,5-dichlorophenyl)-4,4,4-trifluoro-but-2-enoyl]-2,3-dihydro-1H-inden-1-yl}propionamide; With hydroxylamine hydrochloride; In 1,2-dimethoxyethane; water; at 20 ℃; for 0.5h;

With lithium hydroxide monohydrate; In 1,2-dimethoxyethane; water; at 20 ℃;

Reference yield: 77.0%

: 864725-22-4
1,3-dichloro-5-(3,3,3-trifluoroprop-1-en-2-yl)benzene

: 1187245-57-3
N-[5-(hydroxyiminomethyl)-indan-1-yl] propionic acid amide

: 1118626-07-5
N-{5-[5-trifluoromethyl-5-(3,5-dichlorophenyl)-4,5-dihydroisoxazol-3-yl]-2,3-dihydro-1H-inden-1-yl}propionamide

Guidance literature:: N-[5-(hydroxyiminomethyl)-indan-1-yl] propionic acid amide; With N-chloro-succinimide; In N,N-dimethyl-formamide; at 50 ℃; for 1h;

1,3-dichloro-5-(3,3,3-trifluoroprop-1-en-2-yl)benzene; With triethylamine; In N,N-dimethyl-formamide; at 0 - 20 ℃;

Reference yield:

: 1118683-44-5
N-(5-bromo-2,3-dihydro-1H-inden-1-yl)propionamide

: 1118626-07-5
N-{5-[5-trifluoromethyl-5-(3,5-dichlorophenyl)-4,5-dihydroisoxazol-3-yl]-2,3-dihydro-1H-inden-1-yl}propionamide

Guidance literature:: Multi-step reaction with 4 steps

1.1: potassium carbonate; 1,3-bis-(diphenylphosphino)propane; -butyl vinyl ether / water; N,N-dimethyl-formamide / 80 °C / Inert atmosphere

2.1: tributyl-amine / toluene / 60 °C

3.1: acetic anhydride; dmap; triethylamine / toluene / 2 h / 60 °C

4.1: hydroxylamine hydrochloride / water; 1,2-dimethoxyethane / 0.5 h / 20 °C

4.2: 20 °C

With dmap; -butyl vinyl ether; tributyl-amine; 1,3-bis-(diphenylphosphino)propane; hydroxylamine hydrochloride; acetic anhydride; potassium carbonate; triethylamine; In 1,2-dimethoxyethane; water; N,N-dimethyl-formamide; toluene;