864725-22-4

Usage

Uses

Used in Pharmaceutical Industry:
1,3-dichloro-5-(3,3,3-trifluoroprop-1-en-2-yl)benzene is used as a key intermediate in the synthesis of pharmaceuticals for its ability to contribute to the development of novel drug molecules with enhanced properties. Its unique structure allows for the creation of new compounds with potential therapeutic applications.
Used in Pesticide Industry:
In the pesticide industry, 1,3-dichloro-5-(3,3,3-trifluoroprop-1-en-2-yl)benzene is employed as a precursor in the production of various pesticides. Its chemical properties enable the development of effective pest control agents that can protect crops and enhance agricultural productivity.
Used in Dye and Fragrance Industry:
1,3-dichloro-5-(3,3,3-trifluoroprop-1-en-2-yl)benzene is used as a starting material in the synthesis of dyes and fragrances, contributing to the creation of a wide range of colorants and aromatic compounds used in various applications, from textiles to perfumery.
Safety Precautions:
Given its flammable nature and potential to cause skin and eye irritation, 1,3-dichloro-5-(3,3,3-trifluoroprop-1-en-2-yl)benzene requires careful handling and adherence to proper safety measures in both laboratory and industrial settings. Users must follow established protocols to minimize risks associated with its use.

Upstream product

• 1514-82-5 2-bromo-3,3,3-trifluoropropene 
• 626-43-7 3,5-Dichloroaniline 
• 130336-16-2 3,5-dichloro-2,2,2-trifluoroacetophenone 
• 68716-51-8 2-(3,5-dichlorophenyl)-4,4,5,5-tetramethyl-1,3,2-dioxaborolane 
• 19752-55-7 1-bromo-3,5-dichlorobenzene 
• 2065-66-9 methyl-triphenylphosphonium iodide 
• 1031-15-8 methyltriphenylphosphonium chloride 
• 1779-49-3 Methyltriphenylphosphonium bromide 
• 677-21-4 1,1,1-trifluoropropylene 
• 67492-50-6 (3,5-dichlorophenyl)boronic acid 

Downstream Products

• 1070396-55-2 3-[5-(3,5-dichlorophenyl)-5-trifluoromethyl-4,5-dihydroisoxazol-3-yl]nitrobenzene 
• 1231753-86-8 5-[5-(3,5-dichloro-phenyl)-5-trifluoromethyl-4,5-dihydro-isoxazol-3-yl]-3-methyl-thiophene-2-carboxylic acid (2,2,2-trifluoro-ethyl)-amide 
• 1234382-28-5 5-(3,5-dichloro-phenyl)-3-(4-fluoro-naphthalene-1-yl)-5-trifluoromethyl-4,5-dihydro-isoxazole 
• 1067929-24-1 5-(3,5-dichlorophenyl)-3-(4-methylphenyl)-5-(trifluoromethyl)-4,5-dihydroisoxazole 
• 950480-77-0 N-[4-[5-(3,5-dichlorophenyl)-5-trifluoromethyl-4,5-dihydroisoxazol-3-yl]phenylmethyl]acetamide 
• 1233037-40-5 3-(4-bromo-3-chloro-phenyl)-5-(3,5-dichloro-phenyl)-5-trifluoromethyl-4,5-dihydro-isoxazole 
• 1237587-40-4 N′-methyl-N′-{2-chloro-5-[5-(3,5-dichlorophenyl)-5-trifluoro methyl-4,5-dihydroisoxazol-3-yl]phenyl}cyclopropanecarbohydrazide 
• 1237587-25-5 tert-butyl N'-cyclopropanecarbonyl-N-{2-chloro-5-[5-(3,5-dichlorophenyl)-5-trifluoromethyl-4,5-dihydroisoxazol-3-yl]phenyl}carbazate 
• 1237587-26-6 N'-{2-chloro-5-[5-(3,5-dichlorophenyl)-5-(trifluoromethyl)-4,5-dihydroisoxazol-3-yl]phenyl}cyclopropanecarbohydrazide 
• 920502-13-2 C₁₆H₉Cl₂F₄NO 
• 864736-38-9 C₁₇H₈Cl₂F₇NO 
• 1125812-44-3 3-(3-bromo-4-fluorophenyl)-5-(3,5-dichlorophenyl)-4,5-dihydro-5-(trifluoromethyl)isoxazole 
• 1007317-81-8 5-[5-(3,5-dichlorophenyl)-5-(trifluoromethyl)-4,5-dihydroisoxazol-3-yl]-2-fluorobenzonitrile 

Relevant academic research and scientific papers

Site-Selective Defluorinative sp3C-H Alkylation of Secondary Amides

A site-selective defluorinative sp3 C-H alkylation of secondary amides that rapidly and reliably incorporates gem-difluoroalkene motifs into previously unfunctionalized sp3 sites is disclosed. This protocol is distinguished by its mild conditions, wide scope, and exquisite site-selectivity, thus unlocking a new platform to introduce carbonyl isosteres at saturated hydrocarbon sites.

Preparation method of fluralaner intermediate 1,3-dichloro-alpha-(trifluoromethyl)styrene

The invention relates to a preparation method of a fluralaner intermediate 1,3-dichloro-alpha-(trifluoromethyl)styrene. 3,5-Dichloroaniline and 2-bromo-3-trifluoropropene are coupled by a one-step method to obtain a target compound 1,3-dichloro-alpha-(trifluoromethyl)styrene, and the invention also provides a chemical equation in the reaction process. A one-pot method is adopted, raw materials are easy to obtain, reaction is simple, commercial operation and large-scale production are facilitated, and the method has huge economic value.

ISOXAZOLINE-SUBSTITUTED BENZAMIDE COMPOUND AND PEST CONTROL AGENT

PROBLEM TO BE SOLVED: To provide a novel pest control agent, especially pesticide or acaricide. SOLUTION: There is provided an isoxazoline-substituted benzamide compound represented by the following formula. X, Y represent a halogen atom or the like, R1 represents -CH=NOR1a, R1a represents a C1 to C6 alkyl group or the like, R3 represents a C1 to C6 haloalkyl group, m represents an integer of 1 to 3, and n represents an integer of 0 or 1. SELECTED DRAWING: None COPYRIGHT: (C)2019,JPOandINPIT

Method for preparing 3,5-dichloro-a-(trifluoromethyl)styrene

The invention discloses a method for preparing 3,5-dichloro-a-(trifluoromethyl)styrene (2). The method comprises the following steps: carrying out a substitution reaction on 3,5-dichlorobromobenzene used as an initial raw material and an organic fluorine

NOVEL ISOXAZOLINES AND THEIR USE IN CONTROLLING PESTS

Disclosed herein are novel isoxazoline compounds of the general formula (I), compositions comprising these novel compounds, and uses of these compounds in the control of pests in both animal health and plant protection contexts. The compounds can be combined with other biologically active materials such as organophosphate pesticides, carbamate -type pesticides, organochlorine type pesticides, pyrethrins/pyrethroids, neonicotinoids, avermectins, milbemycins, benzimidazoles, salicylanilides, substituted phenols, pyrimidines, tetrahydropyrimidines, imidazothiazoles, amino/amido acetonitrile derivatives, febantel, clorsulon, levamisole, morantel, and praziquantel, juvenile hormone mimics and chitin synthesis inhibitors. (I)

BORON-CONTAINING SMALL MOLECULES

This invention provides novel compounds, methods of using the compounds, and pharmaceutical formulations comprising the compounds.

BORON-CONTAINING SMALL MOLECULES

This invention provides novel compounds, methods of using the compounds, and pharmaceutical compositions containing the compounds.

4-Azolylphenyl isoxazoline insecticides acting at the GABA gated chloride channel

Isoxazoline insecticides have been shown to be potent blockers of insect GABA receptors with excellent activity on a broad pest range, including Lepidoptera and Hemiptera. Herein we report on the synthesis, biological activity and mode-of-action for a class of 4-heterocyclic aryl isoxazoline insecticides.

METHOD FOR PREPARING SUBSTITUTED ISOXAZOLINE COMPOUNDS AND THEIR PRECURSORS 4-CHLORO, 4-BROMO- OR 4-IODOBENZALDEHYDE OXIMES

The present invention relates to a method for preparing 4-chloro-, 4-bromo- or 4- iodobenzaldehyde oximes and phenyl-substituted isoxazoline compounds prepared from these oximes.

5-aryl isoxazolines for controlling invertebrate pests

Disclosed are compounds of Formula 1, including all geometric and stereoisomers, N-oxides, and salts thereof wherein A1, A2 and A3 are independently selected from the group consisting of CR3 and N; B1 B2 and B3 are independently selected from the group consisting of CR2 and N; Q is a phenyl ring or a 5- or 6-membered saturated or unsaturated heterocyclic ring, each ring optionally substituted with one or more substituents independently selected from halogen, C1-C6 alkyl, C1-C6 haloalkyl, C3-C6 cycloalkyl, C3-C6 halocycloalkyl, C1-C6 alkoxy, C1-C6 haloalkoxy, C1-C6 alkylthio, C1-C6 haloalkylthio, C1-C6 alkylsulfinyl, C1-C6 haloalkylsufinyl, C1-C6 alkylsulfonyl, C1-C6 haloalkylsulfonyl, —CN, —NO2, —N(R4)R5, —C(W)N(R4)R5, —C(O)OR5 and R8; or —S(O)2N(R21)R22; —S(O)pR25 or —S(O)(═NR28)R29; R1, R2, R3, R4, R5, R8, R21, R22, R25, R28, R29; p and n are as defined in the disclosure. Also disclosed are compositions containing the compounds of Formula 1 and methods for controlling an invertebrate pest comprising contacting the invertebrate pest or its environment with a biologically effective amount of a compound or a composition of the invention.