N-<2-(4'-bromophenyl)-2-hydroxyethyl>-3-chloro-4-methoxyphenethylamine

Base Information

• Chemical Name: N-<2-(4'-bromophenyl)-2-hydroxyethyl>-3-chloro-4-methoxyphenethylamine
• CAS No.: 107128-71-2
• Molecular Formula: C₁₇H₁₉BrClNO₂
• Molecular Weight: 384.7
• Mol file: 107128-71-2.mol

Synonyms:N-<2-(4'-bromophenyl)-2-hydroxyethyl>-3-chloro-4-methoxyphenethylamine

Chemical Property of N-<2-(4'-bromophenyl)-2-hydroxyethyl>-3-chloro-4-methoxyphenethylamine

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of N-<2-(4'-bromophenyl)-2-hydroxyethyl>-3-chloro-4-methoxyphenethylamine

There total 3 articles about N-<2-(4'-bromophenyl)-2-hydroxyethyl>-3-chloro-4-methoxyphenethylamine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 40.0%

(+/-)-2-(4-bromophenyl)oxirane (32017-76-8) + 3-chloro-4-methoxyphenethylamine (7569-87-1) → N-<2-(4'-bromophenyl)-2-hydroxyethyl>-3-chloro-4-methoxyphenethylamine (107128-71-2) + 1-(4-Bromo-phenyl)-2-{[2-(4-bromo-phenyl)-2-hydroxy-ethyl]-[2-(3-chloro-4-methoxy-phenyl)-ethyl]-amino}-ethanol

Guidance literature:

In acetonitrile; Heating;

DOI:10.1021/jm00127a005

Reference yield:

4-Methoxyphenethylamine (55-81-2) → N-<2-(4'-bromophenyl)-2-hydroxyethyl>-3-chloro-4-methoxyphenethylamine (107128-71-2)

Guidance literature:

Multi-step reaction with 2 steps

1: 47.4 percent / Cl₂, HCl / H₂O; acetic acid / 0.17 h

2: 40 percent / acetonitrile / Heating

With hydrogenchloride; chlorine; In water; acetic acid; acetonitrile;

DOI:10.1021/jm00127a005

Reference yield:

→ N-<2-(4'-bromophenyl)-2-hydroxyethyl>-3-chloro-4-methoxyphenethylamine (107128-71-2)

Guidance literature:

upstream raw materials:

(+/-)-2-(4-bromophenyl)oxirane

3-chloro-4-methoxyphenethylamine

4-Methoxyphenethylamine

Downstream raw materials:

7-chloro-8-methoxy-1-(4'-iodophenyl)-3-methyl-2,3,4,5-tetrahydro-1H-3-benzazepine

7-chloro-8-methoxy-1-(4'-bromophenyl)-3-methyl-2,3,4,5-tetrahydro-1H-3-benzazepine

7-chloro-8-hydroxy-1-(4'-iodophenyl)-3-methyl-2,3,4,5-tetrahydro-1H-3-benzazepine

7-chloro-8-methoxy-1-(4'-bromophenyl)-2,3,4,5-tetrahydro-1H-3-benzazepine