Technology Process of C15H15F3N4O2
There total 9 articles about C15H15F3N4O2 which
guide to synthetic route it.
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synthetic route:
- Guidance literature:
-
With
ammonia;
In
tetrahydrofuran;
Inert atmosphere;
- Guidance literature:
-
Multi-step reaction with 9 steps
1.1: sodium hydride / N,N-dimethyl-formamide; mineral oil / 1 h / 0 °C
1.2: 14 h / 0 - 60 °C
2.1: thionyl chloride / toluene / 90 °C
3.1: magnesium(II) chloride hexahydrate; sodium monohydrogen sulfide x-hydrate / N,N-dimethyl-formamide / 20 °C
4.1: diethyl ether / 20 °C
5.1: N,N-dimethyl-formamide / 2 h / Reflux
6.1: dichloromethane / 0.5 h / 15 °C
7.1: water; lithium hydroxide / tetrahydrofuran / 20 °C
8.1: 4-methyl-morpholine / tetrahydrofuran / 1 h / 0 °C / Inert atmosphere
9.1: ammonia / tetrahydrofuran / Inert atmosphere
With
4-methyl-morpholine; thionyl chloride; sodium monohydrogen sulfide x-hydrate; magnesium(II) chloride hexahydrate; ammonia; water; sodium hydride; lithium hydroxide;
In
tetrahydrofuran; diethyl ether; dichloromethane; N,N-dimethyl-formamide; toluene; mineral oil;
- Guidance literature:
-
Multi-step reaction with 6 steps
1: diethyl ether / 20 °C
2: N,N-dimethyl-formamide / 2 h / Reflux
3: dichloromethane / 0.5 h / 15 °C
4: water; lithium hydroxide / tetrahydrofuran / 20 °C
5: 4-methyl-morpholine / tetrahydrofuran / 1 h / 0 °C / Inert atmosphere
6: ammonia / tetrahydrofuran / Inert atmosphere
With
4-methyl-morpholine; ammonia; water; lithium hydroxide;
In
tetrahydrofuran; diethyl ether; dichloromethane; N,N-dimethyl-formamide;