(isobutylcarbonic) (Z)-3-(3-(3-isopropoxy-5-(trifluoromethyl)phenyl)-1H-1,2,4-triazol-1-yl)acrylic anhydride

Base Information

Chemical Name:(isobutylcarbonic) (Z)-3-(3-(3-isopropoxy-5-(trifluoromethyl)phenyl)-1H-1,2,4-triazol-1-yl)acrylic anhydride
CAS No.:1333153-57-3
Molecular Formula:C₂₀H₂₂F₃N₃O₅
Molecular Weight:441.407
Hs Code.:

Synonyms:(isobutylcarbonic) (Z)-3-(3-(3-isopropoxy-5-(trifluoromethyl)phenyl)-1H-1,2,4-triazol-1-yl)acrylic anhydride

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Chemical Property of (isobutylcarbonic) (Z)-3-(3-(3-isopropoxy-5-(trifluoromethyl)phenyl)-1H-1,2,4-triazol-1-yl)acrylic anhydride

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Technology Process of (isobutylcarbonic) (Z)-3-(3-(3-isopropoxy-5-(trifluoromethyl)phenyl)-1H-1,2,4-triazol-1-yl)acrylic anhydride

There total 8 articles about (isobutylcarbonic) (Z)-3-(3-(3-isopropoxy-5-(trifluoromethyl)phenyl)-1H-1,2,4-triazol-1-yl)acrylic anhydride which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1333153-86-8
(Z)-3-(3-(3-isopropoxy-5-(trifluoromethyl)phenyl)-1H-1,2,4-triazol-1-yl)acrylic acid

: 543-27-1
isobutyl chloroformate

: 1333153-57-3
(isobutylcarbonic) (Z)-3-(3-(3-isopropoxy-5-(trifluoromethyl)phenyl)-1H-1,2,4-triazol-1-yl)acrylic anhydride

Guidance literature:: With 4-methyl-morpholine; In tetrahydrofuran; at 0 ℃; for 1h; Inert atmosphere;

Reference yield:

: 149793-69-1
3-fluoro-5-trifluoromethyl-benzonitrile

: 1333153-57-3
(isobutylcarbonic) (Z)-3-(3-(3-isopropoxy-5-(trifluoromethyl)phenyl)-1H-1,2,4-triazol-1-yl)acrylic anhydride

Guidance literature:: Multi-step reaction with 8 steps

1.1: sodium hydride / N,N-dimethyl-formamide; mineral oil / 1 h / 0 °C

1.2: 14 h / 0 - 60 °C

2.1: thionyl chloride / toluene / 90 °C

3.1: magnesium(II) chloride hexahydrate; sodium monohydrogen sulfide x-hydrate / N,N-dimethyl-formamide / 20 °C

4.1: diethyl ether / 20 °C

5.1: N,N-dimethyl-formamide / 2 h / Reflux

6.1: dichloromethane / 0.5 h / 15 °C

7.1: water; lithium hydroxide / tetrahydrofuran / 20 °C

8.1: 4-methyl-morpholine / tetrahydrofuran / 1 h / 0 °C / Inert atmosphere

With 4-methyl-morpholine; thionyl chloride; sodium monohydrogen sulfide x-hydrate; magnesium(II) chloride hexahydrate; water; sodium hydride; lithium hydroxide; In tetrahydrofuran; diethyl ether; dichloromethane; N,N-dimethyl-formamide; toluene; mineral oil;

Reference yield:

: 1333153-40-4
3-isopropoxy-5-(trifluoromethyl)benzothioamide

: 1333153-57-3
(isobutylcarbonic) (Z)-3-(3-(3-isopropoxy-5-(trifluoromethyl)phenyl)-1H-1,2,4-triazol-1-yl)acrylic anhydride

Guidance literature:: Multi-step reaction with 5 steps

1: diethyl ether / 20 °C

2: N,N-dimethyl-formamide / 2 h / Reflux

3: dichloromethane / 0.5 h / 15 °C

4: water; lithium hydroxide / tetrahydrofuran / 20 °C

5: 4-methyl-morpholine / tetrahydrofuran / 1 h / 0 °C / Inert atmosphere

With 4-methyl-morpholine; water; lithium hydroxide; In tetrahydrofuran; diethyl ether; dichloromethane; N,N-dimethyl-formamide;