Technology Process of tert-butyl (1S,2R)-2-(4-(3-(2H-1,2,3-triazol-2-yl)phenylamino)-5-carbamoylpyrimidin-2-ylamino)cyclohexylcarbamate
There total 15 articles about tert-butyl (1S,2R)-2-(4-(3-(2H-1,2,3-triazol-2-yl)phenylamino)-5-carbamoylpyrimidin-2-ylamino)cyclohexylcarbamate which
guide to synthetic route it.
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synthetic route:
- Guidance literature:
-
Multi-step reaction with 5 steps
1.1: triethylamine / 0 - 20 °C / Large scale
2.1: triethylamine / dichloromethane / 0.17 h / 5 °C / Large scale
2.2: 2 h / 20 °C / Large scale
3.1: sodium azide; 15-crown-5 / N,N-dimethyl-formamide / 6 h / 100 °C
4.1: hydrogen; palladium 10% on activated carbon / methanol / 750.08 Torr
5.1: 3-chloro-benzenecarboperoxoic acid / 1-methyl-pyrrolidin-2-one / 4 h / 5 - 40 °C
5.2: 2 h / 60 - 70 °C
With
sodium azide; 15-crown-5; palladium 10% on activated carbon; hydrogen; triethylamine; 3-chloro-benzenecarboperoxoic acid;
In
1-methyl-pyrrolidin-2-one; methanol; dichloromethane; N,N-dimethyl-formamide;
- Guidance literature:
-
Multi-step reaction with 3 steps
1.1: triethylamine / ethanol / 7 h / 20 - 40 °C / Inert atmosphere; Large scale
2.1: formamide; sodium ethanolate / N,N-dimethyl-formamide / 4 h / 20 - 70 °C / Large scale
3.1: 3-chloro-benzenecarboperoxoic acid / 1-methyl-pyrrolidin-2-one / 4 h / 5 - 40 °C
3.2: 2 h / 60 - 70 °C
With
sodium ethanolate; formamide; triethylamine; 3-chloro-benzenecarboperoxoic acid;
In
1-methyl-pyrrolidin-2-one; ethanol; N,N-dimethyl-formamide;
- Guidance literature:
-
Multi-step reaction with 3 steps
1.1: hydrogenchloride / ethanol / 2 h / 0 - 5 °C / Inert atmosphere; Large scale
1.2: 20 °C / Inert atmosphere; Large scale
2.1: (R)-Mandelic Acid / ethyl acetate / Large scale
2.2: 3 h / 20 - 30 °C / Large scale
3.1: 3-chloro-benzenecarboperoxoic acid / 1-methyl-pyrrolidin-2-one / 4 h / 5 - 40 °C
3.2: 2 h / 60 - 70 °C
With
hydrogenchloride; (R)-Mandelic Acid; 3-chloro-benzenecarboperoxoic acid;
In
1-methyl-pyrrolidin-2-one; ethanol; ethyl acetate;
