benzoic acid 2-(4,5-dimethyloxazol-2-yl)-1-phenylvinyl ester

Base Information

• Chemical Name: benzoic acid 2-(4,5-dimethyloxazol-2-yl)-1-phenylvinyl ester
• CAS No.: 1256960-47-0
• Molecular Formula: C₂₀H₁₇NO₃
• Molecular Weight: 319.36
• Mol file: 1256960-47-0.mol

Synonyms:benzoic acid 2-(4,5-dimethyloxazol-2-yl)-1-phenylvinyl ester

Chemical Property of benzoic acid 2-(4,5-dimethyloxazol-2-yl)-1-phenylvinyl ester

Chemical Property:

Purity/Quality:

Safty Information:

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MSDS Files:

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Technology Process of benzoic acid 2-(4,5-dimethyloxazol-2-yl)-1-phenylvinyl ester

There total 1 articles about benzoic acid 2-(4,5-dimethyloxazol-2-yl)-1-phenylvinyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 79.0%

2,4,5-trimethyloxazole (20662-84-4) + benzoyl chloride (98-88-4) → benzoic acid 2-(4,5-dimethyloxazol-2-yl)-1-phenylvinyl ester (1256960-47-0)

Guidance literature:

With triethylamine; In acetonitrile; for 7h; Inert atmosphere; Reflux;

DOI:10.1055/s-0032-1316790

Reference yield: 74.0%

benzoic acid 2-(4,5-dimethyloxazol-2-yl)-1-phenylvinyl ester (1256960-47-0) → 2-(4,5-dimethyloxazol-2-yl)-1-phenylethanone (1418309-95-1)

Guidance literature:

With potassium hydroxide; In acetonitrile; at 20 ℃; for 24h; Inert atmosphere;

DOI:10.1055/s-0032-1316790

Reference yield:

benzoic acid 2-(4,5-dimethyloxazol-2-yl)-1-phenylvinyl ester (1256960-47-0) → methyl (2E)-3-[4,5-dimethyl-2-(2-oxo-2-phenylethylidene)-1,3-oxazol-3(2H)-yl]acrylate (1419382-37-8)

Guidance literature:

Multi-step reaction with 2 steps

1: potassium hydroxide / acetonitrile / 24 h / 20 °C / Inert atmosphere

2: methanol / 27 h / Inert atmosphere; Reflux

With potassium hydroxide; In methanol; acetonitrile;

DOI:10.1055/s-0032-1316790

upstream raw materials:

2,4,5-trimethyloxazole

benzoyl chloride

Downstream raw materials:

2-(4,5-dimethyloxazol-2-yl)-1-phenylethanone

methyl 8-benzoyl-2,3-dimethyl-5-oxo-5H-[1,3]oxazolo[3,2-a]pyridine-7-carboxylate

tetramethyl 6-(4,5-dimethyl-1,3-oxazol-2-yl)biphenyl-2,3,4,5-tetracarboxylate

methyl (2E)-3-[4,5-dimethyl-2-(2-oxo-2-phenylethylidene)-1,3-oxazol-3(2H)-yl]acrylate