2-(2,4-difluorophenyl)-1,1-difluoro-1-(5-(3-isopropoxypropyl)pyridin-2-yl)-3-(1H-tetrazol-1-yl)propan-2-ol

Base Information

Chemical Name:2-(2,4-difluorophenyl)-1,1-difluoro-1-(5-(3-isopropoxypropyl)pyridin-2-yl)-3-(1H-tetrazol-1-yl)propan-2-ol
CAS No.:1416732-95-0
Molecular Formula:C₂₁H₂₃F₄N₅O₂
Molecular Weight:453.44
Hs Code.:

Synonyms:2-(2,4-difluorophenyl)-1,1-difluoro-1-(5-(3-isopropoxypropyl)pyridin-2-yl)-3-(1H-tetrazol-1-yl)propan-2-ol

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Chemical Property of 2-(2,4-difluorophenyl)-1,1-difluoro-1-(5-(3-isopropoxypropyl)pyridin-2-yl)-3-(1H-tetrazol-1-yl)propan-2-ol

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Technology Process of 2-(2,4-difluorophenyl)-1,1-difluoro-1-(5-(3-isopropoxypropyl)pyridin-2-yl)-3-(1H-tetrazol-1-yl)propan-2-ol

There total 7 articles about 2-(2,4-difluorophenyl)-1,1-difluoro-1-(5-(3-isopropoxypropyl)pyridin-2-yl)-3-(1H-tetrazol-1-yl)propan-2-ol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1416732-93-8
(E)-2-(2,4-difluorophenyl)-1,1-difluoro-1-(5-(3-isopropoxyprop-1-en-1-yl)pyridin-2-yl)-3-(1H-tetrazol-1-yl)propan-2-ol

: 1416732-95-0
2-(2,4-difluorophenyl)-1,1-difluoro-1-(5-(3-isopropoxypropyl)pyridin-2-yl)-3-(1H-tetrazol-1-yl)propan-2-ol

Guidance literature:: With hydrogen; palladium-on-charcoal; In methanol; for 2h;

Reference yield:

: 624-28-2
2,5-dibromopyridine

: 1416732-95-0
2-(2,4-difluorophenyl)-1,1-difluoro-1-(5-(3-isopropoxypropyl)pyridin-2-yl)-3-(1H-tetrazol-1-yl)propan-2-ol

Guidance literature:: Multi-step reaction with 6 steps

1.1: copper / dimethyl sulfoxide / 1 h / 20 °C

1.2: 15 h / 20 °C

2.1: n-butyllithium / hexane; diethyl ether / -70 - 20 °C

3.1: diethyl ether / 0 - 20 °C

4.1: triethylamine; tris-(o-tolyl)phosphine / palladium diacetate / acetonitrile / 18 h / 90 °C / Inert atmosphere

5.1: potassium carbonate / N,N-dimethyl-formamide / 20 - 65 °C / Inert atmosphere

6.1: hydrogen / palladium-on-charcoal / methanol / 2 h

With n-butyllithium; hydrogen; copper; potassium carbonate; triethylamine; tris-(o-tolyl)phosphine; palladium-on-charcoal; palladium diacetate; In methanol; diethyl ether; hexane; dimethyl sulfoxide; N,N-dimethyl-formamide; acetonitrile;

Reference yield:

: 294181-95-6
2-(5-bromopyridine-2-yl)-2,2-difluoroacetic acid ethyl ester

: 1416732-95-0
2-(2,4-difluorophenyl)-1,1-difluoro-1-(5-(3-isopropoxypropyl)pyridin-2-yl)-3-(1H-tetrazol-1-yl)propan-2-ol

Guidance literature:: Multi-step reaction with 5 steps

1: n-butyllithium / hexane; diethyl ether / -70 - 20 °C

2: diethyl ether / 0 - 20 °C

3: triethylamine; tris-(o-tolyl)phosphine / palladium diacetate / acetonitrile / 18 h / 90 °C / Inert atmosphere

4: potassium carbonate / N,N-dimethyl-formamide / 20 - 65 °C / Inert atmosphere

5: hydrogen / palladium-on-charcoal / methanol / 2 h

With n-butyllithium; hydrogen; potassium carbonate; triethylamine; tris-(o-tolyl)phosphine; palladium-on-charcoal; palladium diacetate; In methanol; diethyl ether; hexane; N,N-dimethyl-formamide; acetonitrile;