1-(R)-(N-cyclohexylcarboxamidomethyl)-2-(4-methoxyphenyl)-1,2,3,4-tetrahydroisoquinoline

Base Information

Chemical Name:1-(R)-(N-cyclohexylcarboxamidomethyl)-2-(4-methoxyphenyl)-1,2,3,4-tetrahydroisoquinoline
CAS No.:1447933-71-2
Molecular Formula:C₂₄H₃₀N₂O₂
Molecular Weight:378.514
Hs Code.:

Synonyms:1-(R)-(N-cyclohexylcarboxamidomethyl)-2-(4-methoxyphenyl)-1,2,3,4-tetrahydroisoquinoline

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Chemical Property of 1-(R)-(N-cyclohexylcarboxamidomethyl)-2-(4-methoxyphenyl)-1,2,3,4-tetrahydroisoquinoline

Chemical Property:

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Technology Process of 1-(R)-(N-cyclohexylcarboxamidomethyl)-2-(4-methoxyphenyl)-1,2,3,4-tetrahydroisoquinoline

There total 6 articles about 1-(R)-(N-cyclohexylcarboxamidomethyl)-2-(4-methoxyphenyl)-1,2,3,4-tetrahydroisoquinoline which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 86.0%

: 1447933-67-6
1-(R)-(aminomethyl)-2-(4-methoxyphenyl)-1,2,3,4-tetrahydroisoquinoline

: 2719-27-9
cyclohexanylcarbonyl chloride

: 1447933-71-2
1-(R)-(N-cyclohexylcarboxamidomethyl)-2-(4-methoxyphenyl)-1,2,3,4-tetrahydroisoquinoline

Guidance literature:: With dmap; triethylamine; In dichloromethane; Cooling with ice;
DOI:10.1039/c3ob40503f

Reference yield:

: 91-21-4
1,2,3,4-tetrahydroisoquinoline

: 1447933-71-2
1-(R)-(N-cyclohexylcarboxamidomethyl)-2-(4-methoxyphenyl)-1,2,3,4-tetrahydroisoquinoline

Guidance literature:: Multi-step reaction with 5 steps

1.1: potassium phosphate; copper(l) iodide / ethylene glycol; isopropyl alcohol / 24 h / 80 °C

2.1: 2,3-dicyano-5,6-dichloro-p-benzoquinone / 0.5 h / 20 °C

2.2: 20 °C

3.1: ammonia; hydrogen / methanol / 4 h / 20 °C / 5171.62 Torr

4.1: (-)-Dibenzoyl-L-tartaric acid / isopropyl alcohol; water / 24 h / 20 °C

5.1: triethylamine; dmap / dichloromethane / Cooling with ice

With dmap; potassium phosphate; copper(l) iodide; ammonia; hydrogen; (-)-Dibenzoyl-L-tartaric acid; triethylamine; 2,3-dicyano-5,6-dichloro-p-benzoquinone; In methanol; dichloromethane; water; ethylene glycol; isopropyl alcohol;
DOI:10.1039/c3ob40503f

Reference yield:

: 1132765-82-2
1-(aminomethyl)-2-(4-methoxyphenyl)-1,2,3,4-tetrahydroisoquinoline

: 1447933-71-2
1-(R)-(N-cyclohexylcarboxamidomethyl)-2-(4-methoxyphenyl)-1,2,3,4-tetrahydroisoquinoline

Guidance literature:: Multi-step reaction with 2 steps

1: (-)-Dibenzoyl-L-tartaric acid / isopropyl alcohol; water / 24 h / 20 °C

2: triethylamine; dmap / dichloromethane / Cooling with ice

With dmap; (-)-Dibenzoyl-L-tartaric acid; triethylamine; In dichloromethane; water; isopropyl alcohol;
DOI:10.1039/c3ob40503f