(S)-1-[(1,2,3,4-tetrahydroisoquinolin-1-ylmethyl)]cyclohexanecarboxylic acid amide

Base Information

Chemical Name:(S)-1-[(1,2,3,4-tetrahydroisoquinolin-1-ylmethyl)]cyclohexanecarboxylic acid amide
CAS No.:60567-47-7
Molecular Formula:C₁₇H₂₄N₂O
Molecular Weight:272.39
Hs Code.:

Synonyms:(S)-1-[(1,2,3,4-tetrahydroisoquinolin-1-ylmethyl)]cyclohexanecarboxylic acid amide

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Chemical Property of (S)-1-[(1,2,3,4-tetrahydroisoquinolin-1-ylmethyl)]cyclohexanecarboxylic acid amide

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Technology Process of (S)-1-[(1,2,3,4-tetrahydroisoquinolin-1-ylmethyl)]cyclohexanecarboxylic acid amide

There total 9 articles about (S)-1-[(1,2,3,4-tetrahydroisoquinolin-1-ylmethyl)]cyclohexanecarboxylic acid amide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 46.0%

: 1447933-71-2
1-(R)-(N-cyclohexylcarboxamidomethyl)-2-(4-methoxyphenyl)-1,2,3,4-tetrahydroisoquinoline

: 60567-47-7
(S)-1-[(1,2,3,4-tetrahydroisoquinolin-1-ylmethyl)]cyclohexanecarboxylic acid amide

Guidance literature:: With ammonium cerium (IV) nitrate; In water; acetonitrile; at 0 ℃; for 0.0833333h;
DOI:10.1039/c3ob40503f

Reference yield:

: 40615-08-5
[(isoquinolin-1-yl)methyl]amine

: 60567-47-7
(S)-1-[(1,2,3,4-tetrahydroisoquinolin-1-ylmethyl)]cyclohexanecarboxylic acid amide

: 765915-89-7
N-[(R)-1-(1,2,3,4-tetrahydroisoquinolin-1-ylmethyl)]cyclohexanecarboxylic acid amide

Guidance literature:: Multi-step reaction with 2 steps

1: sodium hydroxide / water; tetrahydrofuran / 2.5 h / 10 - 15 °C

2: (R)-1-[(S_p)-2-(diphenylphosphanyl)ferrocenyl]ethyldi(3,5-xylyl)phosphane; iodine; hydrogen / 1,4-dioxane; toluene / 16 h / 80 °C / 22502.3 Torr

With (R)-1-[(S_p)-2-(diphenylphosphanyl)ferrocenyl]ethyldi(3,5-xylyl)phosphane; hydrogen; iodine; sodium hydroxide; In tetrahydrofuran; 1,4-dioxane; water; toluene;

Reference yield:

: N-(1-isoquinolin-1-yl-methyl)cyclohexanecarboxylic acid amide

: 60567-47-7
(S)-1-[(1,2,3,4-tetrahydroisoquinolin-1-ylmethyl)]cyclohexanecarboxylic acid amide

: 765915-89-7
N-[(R)-1-(1,2,3,4-tetrahydroisoquinolin-1-ylmethyl)]cyclohexanecarboxylic acid amide

Guidance literature:: With bis(1,5-cyclooctadiene)diiridium(I) dichloride; C₄₀H₄₀FeP₂; hydrogen; In tetrahydrofuran; at 75 ℃; for 24h; under 75007.5 - 82508.3 Torr; Reagent/catalyst; Solvent; Temperature; Pressure; enantioselective reaction; Autoclave;