(S)-(+)-3-(tert-butyldimethylsiloxy)-2-(3-methoxyphenyl)-2-methyl-1-propanol

Base Information

Chemical Name:(S)-(+)-3-(tert-butyldimethylsiloxy)-2-(3-methoxyphenyl)-2-methyl-1-propanol
CAS No.:163981-36-0
Molecular Formula:C₁₇H₃₀O₃Si
Molecular Weight:310.509
Hs Code.:

Synonyms:(S)-(+)-3-(tert-butyldimethylsiloxy)-2-(3-methoxyphenyl)-2-methyl-1-propanol

Suppliers and Price of (S)-(+)-3-(tert-butyldimethylsiloxy)-2-(3-methoxyphenyl)-2-methyl-1-propanol

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 0 raw suppliers

Chemical Property of (S)-(+)-3-(tert-butyldimethylsiloxy)-2-(3-methoxyphenyl)-2-methyl-1-propanol

Chemical Property:

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Technology Process of (S)-(+)-3-(tert-butyldimethylsiloxy)-2-(3-methoxyphenyl)-2-methyl-1-propanol

There total 9 articles about (S)-(+)-3-(tert-butyldimethylsiloxy)-2-(3-methoxyphenyl)-2-methyl-1-propanol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 90.0%

: 187725-53-7
Acetic acid (S)-3-(tert-butyl-dimethyl-silanyloxy)-2-(3-methoxy-phenyl)-2-methyl-propyl ester

: 163981-36-0
(S)-(+)-3-(tert-butyldimethylsiloxy)-2-(3-methoxyphenyl)-2-methyl-1-propanol

Guidance literature:: With potassium carbonate; In methanol; for 2h; Ambient temperature;
DOI:10.1016/S0957-4166(96)00500-9

Reference yield:

: 163981-35-9
(R)-(+)-methyl 3-(tert-butyldimethylsilyloxy)-2-(3-methoxyphenyl)-2-methylpropionate

: (R)-3-(tert-butyldimethylsilyloxy)-2-(3-methoxyphenyl)-2-methylpropanol

: 163981-36-0
(S)-(+)-3-(tert-butyldimethylsiloxy)-2-(3-methoxyphenyl)-2-methyl-1-propanol

Guidance literature:: With diisobutylaluminium hydride; In hexane; at -78 ℃; for 0.5h; Yield given. Yields of byproduct given. Title compound not separated from byproducts;
DOI:10.1016/0957-4166(95)00097-9

Reference yield:

: dimethyl 2-methyl-2-(3-methoxyphenyl)malonate

: 163981-36-0
(S)-(+)-3-(tert-butyldimethylsiloxy)-2-(3-methoxyphenyl)-2-methyl-1-propanol

Guidance literature:: Multi-step reaction with 4 steps

1: 86 percent / LiAlH₄ / diethyl ether / 6 h / Heating

2: various solvent(s) / 96 h / Ambient temperature; lipase from Pseudomonas cepacia immobilized on Hyflo Super Cell

3: 92 percent / DMAP / CH₂Cl₂ / 10 h / Ambient temperature

4: 90 percent / K₂CO₃ / methanol / 2 h / Ambient temperature

With dmap; lithium aluminium tetrahydride; potassium carbonate; In methanol; diethyl ether; dichloromethane;
DOI:10.1016/S0957-4166(96)00500-9