4-[(2-fluoro-5-methylphenyl)amino]-6,7-dimethoxycinnoline-3-carboxamide

Base Information

Chemical Name:4-[(2-fluoro-5-methylphenyl)amino]-6,7-dimethoxycinnoline-3-carboxamide
CAS No.:1041852-40-7
Molecular Formula:C₁₈H₁₇FN₄O₃
Molecular Weight:356.356
Hs Code.:

Synonyms:4-[(2-fluoro-5-methylphenyl)amino]-6,7-dimethoxycinnoline-3-carboxamide

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Chemical Property of 4-[(2-fluoro-5-methylphenyl)amino]-6,7-dimethoxycinnoline-3-carboxamide

Chemical Property:

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Technology Process of 4-[(2-fluoro-5-methylphenyl)amino]-6,7-dimethoxycinnoline-3-carboxamide

There total 7 articles about 4-[(2-fluoro-5-methylphenyl)amino]-6,7-dimethoxycinnoline-3-carboxamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 96.0%

: 1041853-34-2
ethyl 4-[(2-fluoro-5-methylphenyl)amino]-6,7-dimethoxycinnoline-3-carboxylate

: 1041852-40-7
4-[(2-fluoro-5-methylphenyl)amino]-6,7-dimethoxycinnoline-3-carboxamide

Guidance literature:: With sodium methylate; formamide; In methanol; N,N-dimethyl-formamide; at 100 ℃;
DOI:10.1016/j.bmcl.2011.01.033

Reference yield:

: 4101-30-8
2-amino-4,5-dimethoxyacetophenone

: 1041852-40-7
4-[(2-fluoro-5-methylphenyl)amino]-6,7-dimethoxycinnoline-3-carboxamide

Guidance literature:: Multi-step reaction with 6 steps

1: hydrogenchloride; sodium nitrite / water / 0 °C

2: sodium hydride / tetrahydrofuran / Reflux

3: trifluoroacetic acid / 0 °C

4: trichlorophosphate / Reflux

5: acetic acid / ethanol / 75 °C

6: sodium methylate; formamide / methanol; N,N-dimethyl-formamide / 100 °C

With hydrogenchloride; sodium methylate; sodium hydride; formamide; acetic acid; trifluoroacetic acid; sodium nitrite; trichlorophosphate; In tetrahydrofuran; methanol; ethanol; water; N,N-dimethyl-formamide;
DOI:10.1016/j.bmcl.2011.01.033

Reference yield:

: 1284175-28-5
C₁₄H₁₉N₃O₃

: 1041852-40-7
4-[(2-fluoro-5-methylphenyl)amino]-6,7-dimethoxycinnoline-3-carboxamide

Guidance literature:: Multi-step reaction with 5 steps

1: sodium hydride / tetrahydrofuran / Reflux

2: trifluoroacetic acid / 0 °C

3: trichlorophosphate / Reflux

4: acetic acid / ethanol / 75 °C

5: sodium methylate; formamide / methanol; N,N-dimethyl-formamide / 100 °C

With sodium methylate; sodium hydride; formamide; acetic acid; trifluoroacetic acid; trichlorophosphate; In tetrahydrofuran; methanol; ethanol; N,N-dimethyl-formamide;
DOI:10.1016/j.bmcl.2011.01.033