6-Benzyl-5-ethyl-1-(2-methoxy-ethyl)-3-(2-oxo-2-phenyl-ethyl)-1H-pyrimidine-2,4-dione

Base Information

Chemical Name:6-Benzyl-5-ethyl-1-(2-methoxy-ethyl)-3-(2-oxo-2-phenyl-ethyl)-1H-pyrimidine-2,4-dione
CAS No.:1026964-03-3
Molecular Formula:C₂₄H₂₆N₂O₄
Molecular Weight:406.481
Hs Code.:

Synonyms:6-Benzyl-5-ethyl-1-(2-methoxy-ethyl)-3-(2-oxo-2-phenyl-ethyl)-1H-pyrimidine-2,4-dione

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Chemical Property of 6-Benzyl-5-ethyl-1-(2-methoxy-ethyl)-3-(2-oxo-2-phenyl-ethyl)-1H-pyrimidine-2,4-dione

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Technology Process of 6-Benzyl-5-ethyl-1-(2-methoxy-ethyl)-3-(2-oxo-2-phenyl-ethyl)-1H-pyrimidine-2,4-dione

There total 8 articles about 6-Benzyl-5-ethyl-1-(2-methoxy-ethyl)-3-(2-oxo-2-phenyl-ethyl)-1H-pyrimidine-2,4-dione which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 100-52-7
benzaldehyde

: 1026964-03-3
6-Benzyl-5-ethyl-1-(2-methoxy-ethyl)-3-(2-oxo-2-phenyl-ethyl)-1H-pyrimidine-2,4-dione

Guidance literature:: Multi-step reaction with 6 steps

1: 1.) LDA / 1.) THF, -70 deg C, 1 h, 2.) THF, -70 deg C, 1 h

2: pyridine / 12 h / Ambient temperature

3: 88 percent / H₂, aq. AcOH / 10percent Pd/C / dioxane / 15 h / 60 °C / 760 Torr

4: K₂CO₃ / acetonitrile / 2 h / Heating

5: 90percent aq. TFA / 1 h / Heating

6: K₂CO₃ / dimethylsulfoxide / 0.33 h / 80 °C

With pyridine; hydrogen; potassium carbonate; acetic acid; trifluoroacetic acid; lithium diisopropyl amide; palladium on activated charcoal; In 1,4-dioxane; dimethyl sulfoxide; acetonitrile;
DOI:10.1021/jm00015a008

Reference yield:

: 136160-48-0
1-(ethoxymethyl)-5-ethyluracil

: 1026964-03-3
6-Benzyl-5-ethyl-1-(2-methoxy-ethyl)-3-(2-oxo-2-phenyl-ethyl)-1H-pyrimidine-2,4-dione

Guidance literature:: Multi-step reaction with 6 steps

1: 1.) LDA / 1.) THF, -70 deg C, 1 h, 2.) THF, -70 deg C, 1 h

2: pyridine / 12 h / Ambient temperature

3: 88 percent / H₂, aq. AcOH / 10percent Pd/C / dioxane / 15 h / 60 °C / 760 Torr

4: K₂CO₃ / acetonitrile / 2 h / Heating

5: 90percent aq. TFA / 1 h / Heating

6: K₂CO₃ / dimethylsulfoxide / 0.33 h / 80 °C

With pyridine; hydrogen; potassium carbonate; acetic acid; trifluoroacetic acid; lithium diisopropyl amide; palladium on activated charcoal; In 1,4-dioxane; dimethyl sulfoxide; acetonitrile;
DOI:10.1021/jm00015a008

Reference yield:

: 1026724-09-3
1-Ethoxymethyl-5-ethyl-6-(hydroxy-phenyl-methyl)-1H-pyrimidine-2,4-dione

: 1026964-03-3
6-Benzyl-5-ethyl-1-(2-methoxy-ethyl)-3-(2-oxo-2-phenyl-ethyl)-1H-pyrimidine-2,4-dione

Guidance literature:: Multi-step reaction with 5 steps

1: pyridine / 12 h / Ambient temperature

2: 88 percent / H₂, aq. AcOH / 10percent Pd/C / dioxane / 15 h / 60 °C / 760 Torr

3: K₂CO₃ / acetonitrile / 2 h / Heating

4: 90percent aq. TFA / 1 h / Heating

5: K₂CO₃ / dimethylsulfoxide / 0.33 h / 80 °C

With pyridine; hydrogen; potassium carbonate; acetic acid; trifluoroacetic acid; palladium on activated charcoal; In 1,4-dioxane; dimethyl sulfoxide; acetonitrile;
DOI:10.1021/jm00015a008