N,N-diallyl-O-tert-butyl-L-tyrosyl-α-aminoisobutyryl-α-aminoisobutyric acid

Base Information

Chemical Name:N,N-diallyl-O-tert-butyl-L-tyrosyl-α-aminoisobutyryl-α-aminoisobutyric acid
CAS No.:109335-00-4
Molecular Formula:C₂₇H₄₁N₃O₅
Molecular Weight:487.64
Hs Code.:

Synonyms:N,N-diallyl-O-tert-butyl-L-tyrosyl-α-aminoisobutyryl-α-aminoisobutyric acid

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of N,N-diallyl-O-tert-butyl-L-tyrosyl-α-aminoisobutyryl-α-aminoisobutyric acid

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Technology Process of N,N-diallyl-O-tert-butyl-L-tyrosyl-α-aminoisobutyryl-α-aminoisobutyric acid

There total 7 articles about N,N-diallyl-O-tert-butyl-L-tyrosyl-α-aminoisobutyryl-α-aminoisobutyric acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 85.5%

: 109334-99-8
methyl N,N-diallyl-O-tert-butyltyrosyl-α-aminoisobutyryl-α-aminoisobutyrate

: 109335-00-4
N,N-diallyl-O-tert-butyl-L-tyrosyl-α-aminoisobutyryl-α-aminoisobutyric acid

Guidance literature:: With sodium hydroxide; In tetrahydrofuran; methanol; at 0 - 25 ℃; for 2.75h;
DOI:10.1021/jm00392a025

Reference yield:

: 6671-25-6
2-(2-benzyloxycarbonylamino-2-methyl-propionylamino)-2-methylpropionic acid methyl ester

: 109335-00-4
N,N-diallyl-O-tert-butyl-L-tyrosyl-α-aminoisobutyryl-α-aminoisobutyric acid

Guidance literature:: Multi-step reaction with 5 steps

1: 87.2 percent / H₂, conc. HCl / 10percent Pd/C / methanol / 0.75 h / 760 Torr

2: N-methylmorpholine / dimethylformamide; tetrahydrofuran / 1.) -15 deg C, 45 min, 2.) 25 deg C, 2.5 h

3: 73.8 percent / ammonium formate / 10percent Pd/C / methanol / 0.25 h / 25 °C

4: 85.1 percent / N,N-diisopropylethylamine / acetonitrile / 18 h / 25 °C

5: 85.5 percent / 4N NaOH / methanol; tetrahydrofuran / 2.75 h / 0 - 25 °C

With 4-methyl-morpholine; hydrogenchloride; sodium hydroxide; hydrogen; ammonium formate; N-ethyl-N,N-diisopropylamine; palladium on activated charcoal; In tetrahydrofuran; methanol; N,N-dimethyl-formamide; acetonitrile;
DOI:10.1021/jm00392a025

Reference yield:

: 5545-54-0
N-(benzyloxycarbonyl)-O-(1,1-dimethylethyl)-L-tyrosine

: 109335-00-4
N,N-diallyl-O-tert-butyl-L-tyrosyl-α-aminoisobutyryl-α-aminoisobutyric acid

Guidance literature:: Multi-step reaction with 5 steps

1: N-methylmorpholine / tetrahydrofuran / 0.03 h / -18 - -12 °C

2: N-methylmorpholine / dimethylformamide; tetrahydrofuran / 1.) -15 deg C, 45 min, 2.) 25 deg C, 2.5 h

3: 73.8 percent / ammonium formate / 10percent Pd/C / methanol / 0.25 h / 25 °C

4: 85.1 percent / N,N-diisopropylethylamine / acetonitrile / 18 h / 25 °C

5: 85.5 percent / 4N NaOH / methanol; tetrahydrofuran / 2.75 h / 0 - 25 °C

With 4-methyl-morpholine; sodium hydroxide; ammonium formate; N-ethyl-N,N-diisopropylamine; palladium on activated charcoal; In tetrahydrofuran; methanol; N,N-dimethyl-formamide; acetonitrile;
DOI:10.1021/jm00392a025