methyl N,N-diallyl-O-tert-butyltyrosyl-α-aminoisobutyryl-α-aminoisobutyrate

Base Information

Chemical Name:methyl N,N-diallyl-O-tert-butyltyrosyl-α-aminoisobutyryl-α-aminoisobutyrate
CAS No.:109334-99-8
Molecular Formula:C₂₈H₄₃N₃O₅
Molecular Weight:501.667
Hs Code.:

Synonyms:methyl N,N-diallyl-O-tert-butyltyrosyl-α-aminoisobutyryl-α-aminoisobutyrate

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Chemical Property of methyl N,N-diallyl-O-tert-butyltyrosyl-α-aminoisobutyryl-α-aminoisobutyrate

Chemical Property:

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Technology Process of methyl N,N-diallyl-O-tert-butyltyrosyl-α-aminoisobutyryl-α-aminoisobutyrate

There total 6 articles about methyl N,N-diallyl-O-tert-butyltyrosyl-α-aminoisobutyryl-α-aminoisobutyrate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 85.1%

: 106-95-6
allyl bromide

: 109334-98-7
methyl O-tert-butyltyrosyl-α-aminoisobutyryl-α-aminoisobutyrate

: 109334-99-8
methyl N,N-diallyl-O-tert-butyltyrosyl-α-aminoisobutyryl-α-aminoisobutyrate

Guidance literature:: With N-ethyl-N,N-diisopropylamine; In acetonitrile; at 25 ℃; for 18h;
DOI:10.1021/jm00392a025

Reference yield:

: 6671-25-6
2-(2-benzyloxycarbonylamino-2-methyl-propionylamino)-2-methylpropionic acid methyl ester

: 109334-99-8
methyl N,N-diallyl-O-tert-butyltyrosyl-α-aminoisobutyryl-α-aminoisobutyrate

Guidance literature:: Multi-step reaction with 4 steps

1: 87.2 percent / H₂, conc. HCl / 10percent Pd/C / methanol / 0.75 h / 760 Torr

2: N-methylmorpholine / dimethylformamide; tetrahydrofuran / 1.) -15 deg C, 45 min, 2.) 25 deg C, 2.5 h

3: 73.8 percent / ammonium formate / 10percent Pd/C / methanol / 0.25 h / 25 °C

4: 85.1 percent / N,N-diisopropylethylamine / acetonitrile / 18 h / 25 °C

With 4-methyl-morpholine; hydrogenchloride; hydrogen; ammonium formate; N-ethyl-N,N-diisopropylamine; palladium on activated charcoal; In tetrahydrofuran; methanol; N,N-dimethyl-formamide; acetonitrile;
DOI:10.1021/jm00392a025

Reference yield:

: 5545-54-0
N-(benzyloxycarbonyl)-O-(1,1-dimethylethyl)-L-tyrosine

: 109334-99-8
methyl N,N-diallyl-O-tert-butyltyrosyl-α-aminoisobutyryl-α-aminoisobutyrate

Guidance literature:: Multi-step reaction with 4 steps

1: N-methylmorpholine / tetrahydrofuran / 0.03 h / -18 - -12 °C

2: N-methylmorpholine / dimethylformamide; tetrahydrofuran / 1.) -15 deg C, 45 min, 2.) 25 deg C, 2.5 h

3: 73.8 percent / ammonium formate / 10percent Pd/C / methanol / 0.25 h / 25 °C

4: 85.1 percent / N,N-diisopropylethylamine / acetonitrile / 18 h / 25 °C

With 4-methyl-morpholine; ammonium formate; N-ethyl-N,N-diisopropylamine; palladium on activated charcoal; In tetrahydrofuran; methanol; N,N-dimethyl-formamide; acetonitrile;
DOI:10.1021/jm00392a025