ethyl 3-ethoxy-7-[3-((4-ethoxycarbonylphenylamino)carbonyloxymethyl)-4-pyridon-1-yl]-6-nitroquinoxaline-2-carboxylate

Base Information

• Chemical Name: ethyl 3-ethoxy-7-[3-((4-ethoxycarbonylphenylamino)carbonyloxymethyl)-4-pyridon-1-yl]-6-nitroquinoxaline-2-carboxylate
• CAS No.: 221167-14-2
• Molecular Formula: C₂₉H₂₇N₅O₁₀
• Molecular Weight: 605.561
• Mol file: 221167-14-2.mol

Synonyms:ethyl 3-ethoxy-7-[3-((4-ethoxycarbonylphenylamino)carbonyloxymethyl)-4-pyridon-1-yl]-6-nitroquinoxaline-2-carboxylate

Chemical Property of ethyl 3-ethoxy-7-[3-((4-ethoxycarbonylphenylamino)carbonyloxymethyl)-4-pyridon-1-yl]-6-nitroquinoxaline-2-carboxylate

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of ethyl 3-ethoxy-7-[3-((4-ethoxycarbonylphenylamino)carbonyloxymethyl)-4-pyridon-1-yl]-6-nitroquinoxaline-2-carboxylate

There total 11 articles about ethyl 3-ethoxy-7-[3-((4-ethoxycarbonylphenylamino)carbonyloxymethyl)-4-pyridon-1-yl]-6-nitroquinoxaline-2-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 94.0%

p-ethoxycarbonylphenyl isocyanate (30806-83-8) + ethyl 3-ethoxy-7-[3-(hydroxymethyl)-4-pyridon-1-yl]-6-nitroquinoxaline-2-carboxylate (221164-67-6) → ethyl 3-ethoxy-7-[3-((4-ethoxycarbonylphenylamino)carbonyloxymethyl)-4-pyridon-1-yl]-6-nitroquinoxaline-2-carboxylate (221167-14-2)

Guidance literature:

In benzene; for 2h; Heating;

DOI:10.1016/j.bmc.2005.05.030

Reference yield:

4-Chloropyridine (626-61-9) → ethyl 3-ethoxy-7-[3-((4-ethoxycarbonylphenylamino)carbonyloxymethyl)-4-pyridon-1-yl]-6-nitroquinoxaline-2-carboxylate (221167-14-2)

Guidance literature:

Multi-step reaction with 5 steps

1.1: lithium diisopropylamide / tetrahydrofuran; hexane / 0.5 h / -78 °C

1.2: tetrahydrofuran; hexane / -78 - 20 °C

2.1: 7.02 g / sodium borohydride / ethanol / 3 h / 20 °C

3.1: NaOH / H₂O / 24 h / Heating

4.1: 410 mg / dimethylformamide / 4 h / 110 °C

5.1: 94 percent / benzene / 2 h / Heating

With sodium hydroxide; sodium tetrahydroborate; lithium diisopropyl amide; In tetrahydrofuran; ethanol; hexane; water; N,N-dimethyl-formamide; benzene;

DOI:10.1016/j.bmc.2005.05.030

Reference yield:

4-chloro-3-(hydroxymethyl)pyridine (189449-41-0) → ethyl 3-ethoxy-7-[3-((4-ethoxycarbonylphenylamino)carbonyloxymethyl)-4-pyridon-1-yl]-6-nitroquinoxaline-2-carboxylate (221167-14-2)

Guidance literature:

Multi-step reaction with 3 steps

1: NaOH / H₂O / 24 h / Heating

2: 410 mg / dimethylformamide / 4 h / 110 °C

3: 94 percent / benzene / 2 h / Heating

With sodium hydroxide; In water; N,N-dimethyl-formamide; benzene;

DOI:10.1016/j.bmc.2005.05.030

upstream raw materials:

p-ethoxycarbonylphenyl isocyanate

ethyl 3-ethoxy-7-[3-(hydroxymethyl)-4-pyridon-1-yl]-6-nitroquinoxaline-2-carboxylate

4-Chloropyridine

4-chloro-3-(hydroxymethyl)pyridine

Downstream raw materials:

7-[3-((4-ethoxycarbonylphenylamino)carbonyloxymethyl)-4-pyridon-1-yl]-3,4-dihydro-6-nitro-3-oxoquinoxaline-2-carboxylic acid