189449-41-0

Basic information

• Product Name: (4-Chloro-3-pyridinyl)methanol
• Synonyms: 4-chloro-3-PyridineMethanol;(4-Chloropyridin-3-yl)methanol, 4-Chloronicotinyl alcohol;(4-Chloro-3-pyridinyl)methanol;(4-Chloro-pyridin-3-yl)-methanol;3-Pyridinemethanol,4-chloro-(9CI);4-Chloro-3-pyridylcarbinol;4-Chloro-3-(hydroxymethyl)pyridine
• CAS NO: 189449-41-0
• Molecular Formula: C₆H₆ClNO
• Molecular Weight: 143.57
• Product Categories: PYRIDINE;Heterocyclic Compounds
• Mol File: 189449-41-0.mol
• Article Data: 19

Chemical Properties

• Boiling Point: 262.8 °C at 760 mmHg
• Flash Point: 112.7 °C
• Appearance: /
• Density: 1.324 g/cm³
• Vapor Pressure: 0.00539mmHg at 25°C
• Refractive Index: 1.572
• Storage Temp.: under inert gas (nitrogen or Argon) at 2-8°C
• PKA: 13.00±0.10(Predicted)
• CAS DataBase Reference: (4-Chloro-3-pyridinyl)methanol(CAS DataBase Reference)
• NIST Chemistry Reference: (4-Chloro-3-pyridinyl)methanol(189449-41-0)
• EPA Substance Registry System: (4-Chloro-3-pyridinyl)methanol(189449-41-0)

Safety Data

• Hazard Codes: Xi
• HazardClass: IRRITANT
• Hazardous Substances Data: 189449-41-0(Hazardous Substances Data)

Usage

Description

(4-Chloro-3-pyridinyl)methanol, a chemical compound with the molecular formula C6H6ClNO, is a white to off-white crystalline powder. It has a molecular weight of 156.6 g/mol and is known for its versatile chemical properties, making it a valuable intermediate in various industrial applications.

Uses

Used in Pharmaceutical Industry:
(4-Chloro-3-pyridinyl)methanol is used as an intermediate for the synthesis of various pharmaceuticals. Its unique chemical structure allows it to be incorporated into the development of new drugs, contributing to the advancement of medicine.
Used in Agrochemical Industry:
In the agrochemical sector, (4-Chloro-3-pyridinyl)methanol serves as a key intermediate in the production of insecticides and fungicides. Its chemical properties enable it to be formulated into effective pest control agents, helping to protect crops and maintain agricultural productivity.
Used in Organic Synthesis:
(4-Chloro-3-pyridinyl)methanol is utilized as a reagent in organic synthesis, where it can be used to create a variety of chemical compounds. Its versatility in reactions makes it a valuable tool for chemists in the development of new organic compounds.
Used in Fine Chemicals Production:
(4-Chloro-3-pyridinyl)methanol is also employed as an intermediate in the manufacture of other fine chemicals. Its unique properties allow it to be incorporated into the production of specialty chemicals used in various industries, such as fragrances, dyes, and coatings.
Safety Precautions:
It is crucial to handle and store (4-Chloro-3-pyridinyl)methanol according to proper safety guidelines to prevent any potential hazards. Adhering to safety protocols ensures the well-being of individuals and the environment during its use and disposal.

InChI:InChI=1/C6H6ClNO/c7-6-1-2-8-3-5(6)4-9/h1-3,9H,4H2

Upstream product

• 63592-85-8 methyl 4-chloronicotinate 
• 10177-29-4 4-chloronicotinic acid 
• 7379-35-3 4-chlorpyridine hydrochloride 
• 114077-82-6 4-chloronicotinaldehyde 
• 626-61-9 4-Chloropyridine 
• 37831-62-2 ethyl 4-chloronicotinate 

Downstream Products

• 1426165-71-0 1,3'-(E)-ethene-1,2-diyl-1-(2-bromobenzene)-2-(4chloropyridine) 
• 114077-82-6 4-chloronicotinaldehyde 
• 1018953-37-1 1-(thieno[3,2-c]pyridin-2-yl)ethan-1-one 
• 86236-37-5 thieno[3,2-c]pyridine-2-carboxylic acid 
• 221167-14-2 ethyl 3-ethoxy-7-[3-((4-ethoxycarbonylphenylamino)carbonyloxymethyl)-4-pyridon-1-yl]-6-nitroquinoxaline-2-carboxylate 
• 221167-15-3 7-[3-((4-ethoxycarbonylphenylamino)carbonyloxymethyl)-4-pyridon-1-yl]-3,4-dihydro-6-nitro-3-oxoquinoxaline-2-carboxylic acid 
• 142890-84-4 3-(hydroxymethyl)-4(1H)-pyridone 

Relevant articles and documents

Synthesis of conformationally restricted nicotine analogues by intramolecular [3+2] cycloaddition

We describe the synthesis of a series of conformationally constrained nicotine analogues 2-5 from appropriate pyridine-containing enals, featuring an intramolecular azomethine ylide-alkene [3+2] cycloaddition. The objective of the current project is to develop new selective nAChRs-targeting ligands. Of the nicotine analogues that we have studied, the conformation-restricting ring B unit can be either a five-membered carbocycle, or a six-membered carbocycle or heterocycle. The present work constitutes a general method for rapid assembly of other related tricyclic nicotine analogues.

DMAP-thiourea catalyst and preparation method thereof, and high-molecular-weight biodegradable polyester and preparation method thereof

The invention relates to a DMAP-thiourea catalyst and a preparation method thereof as well as high-molecular-weight biodegradable polyester and a preparation method thereof. The DMAP-thiourea catalyst disclosed by the invention has the characteristic of living polymerization when being used for catalyzing ring opening polymerization of O-carboxyl anhydride monomers (OCAs). According to the DMAP-thiourea catalyst disclosed by the invention, a thiourea group is used as Lewis acid, a monomer is activated through a hydrogen bond, DMAP is used as Lewis alkali and a nucleophilic addition monomer, and ring opening polymerization of an OCAs monomer is commonly catalyzed by utilizing an adjacent synergistic effect. Especially, the increased active species are zwitterions, and no alcohol is needed as an initiator. The polymerization speed is high, the reaction temperature is low, and the obtained polyester is high in molecular weight and narrow in distribution. By adjusting the structure of the catalyst, changing the acidity and alkalinity of the catalyst and the steric hindrance of the catalyst and optimizing parameters such as polymerization temperature, concentration and the like, controllable polymerization of the OCAs monomer is realized, and finally, biodegradable polyester with molecular weight as high as 130,000 is obtained.

NOVEL MORPHOLINE DERIVATIVE OR SALT THEREOF

There is provided a morpholine derivative represented by General Formula [1A] or a salt thereof. (In the formula, a ring A represents a ring represented by General Formula [I]; * represents a bonding position; Z2 represents CH or the like; Z1 represents CR6 or the like; R6 represents a hydrogen atom or the like; X1 represents CHR7 or the like; R7 represents a hydrogen atom or the like; X2 represents CH2 or the like; R1 and R2 are the same as or different from each other, and each of R1 and R2 represents a hydrogen atom or the like; R3, R4, and R5 are the same as or different from each other, and each of R3, R4, and R5 represents a hydrogen atom, NRaRb, or the like; and each of Ra and Rb represents a hydrogen atom, a C1-8 alkyl group which may have a substituent, or the like.)