7-[3-((4-ethoxycarbonylphenylamino)carbonyloxymethyl)-4-pyridon-1-yl]-3,4-dihydro-6-nitro-3-oxoquinoxaline-2-carboxylic acid

Base Information

• Chemical Name: 7-[3-((4-ethoxycarbonylphenylamino)carbonyloxymethyl)-4-pyridon-1-yl]-3,4-dihydro-6-nitro-3-oxoquinoxaline-2-carboxylic acid
• CAS No.: 221167-15-3
• Molecular Formula: C₂₅H₁₉N₅O₁₀
• Molecular Weight: 549.453
• Mol file: 221167-15-3.mol

Synonyms:7-[3-((4-ethoxycarbonylphenylamino)carbonyloxymethyl)-4-pyridon-1-yl]-3,4-dihydro-6-nitro-3-oxoquinoxaline-2-carboxylic acid

Chemical Property of 7-[3-((4-ethoxycarbonylphenylamino)carbonyloxymethyl)-4-pyridon-1-yl]-3,4-dihydro-6-nitro-3-oxoquinoxaline-2-carboxylic acid

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 7-[3-((4-ethoxycarbonylphenylamino)carbonyloxymethyl)-4-pyridon-1-yl]-3,4-dihydro-6-nitro-3-oxoquinoxaline-2-carboxylic acid

There total 12 articles about 7-[3-((4-ethoxycarbonylphenylamino)carbonyloxymethyl)-4-pyridon-1-yl]-3,4-dihydro-6-nitro-3-oxoquinoxaline-2-carboxylic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 86.0%

ethyl 3-ethoxy-7-[3-((4-ethoxycarbonylphenylamino)carbonyloxymethyl)-4-pyridon-1-yl]-6-nitroquinoxaline-2-carboxylate (221167-14-2) → 7-[3-((4-ethoxycarbonylphenylamino)carbonyloxymethyl)-4-pyridon-1-yl]-3,4-dihydro-6-nitro-3-oxoquinoxaline-2-carboxylic acid (221167-15-3)

Guidance literature:

With hydrogenchloride; acetic acid; at 20 ℃; for 18h;

DOI:10.1016/j.bmc.2005.05.030

Reference yield:

4-Chloropyridine (626-61-9) → 7-[3-((4-ethoxycarbonylphenylamino)carbonyloxymethyl)-4-pyridon-1-yl]-3,4-dihydro-6-nitro-3-oxoquinoxaline-2-carboxylic acid (221167-15-3)

Guidance literature:

Multi-step reaction with 6 steps

1.1: lithium diisopropylamide / tetrahydrofuran; hexane / 0.5 h / -78 °C

1.2: tetrahydrofuran; hexane / -78 - 20 °C

2.1: 7.02 g / sodium borohydride / ethanol / 3 h / 20 °C

3.1: NaOH / H₂O / 24 h / Heating

4.1: 410 mg / dimethylformamide / 4 h / 110 °C

5.1: 94 percent / benzene / 2 h / Heating

6.1: 86 percent / HCl; AcOH / 18 h / 20 °C

With hydrogenchloride; sodium hydroxide; sodium tetrahydroborate; acetic acid; lithium diisopropyl amide; In tetrahydrofuran; ethanol; hexane; water; N,N-dimethyl-formamide; benzene;

DOI:10.1016/j.bmc.2005.05.030

Reference yield:

4-chloro-3-(hydroxymethyl)pyridine (189449-41-0) → 7-[3-((4-ethoxycarbonylphenylamino)carbonyloxymethyl)-4-pyridon-1-yl]-3,4-dihydro-6-nitro-3-oxoquinoxaline-2-carboxylic acid (221167-15-3)

Guidance literature:

Multi-step reaction with 4 steps

1: NaOH / H₂O / 24 h / Heating

2: 410 mg / dimethylformamide / 4 h / 110 °C

3: 94 percent / benzene / 2 h / Heating

4: 86 percent / HCl; AcOH / 18 h / 20 °C

With hydrogenchloride; sodium hydroxide; acetic acid; In water; N,N-dimethyl-formamide; benzene;

DOI:10.1016/j.bmc.2005.05.030

upstream raw materials:

ethyl 3-ethoxy-7-[3-((4-ethoxycarbonylphenylamino)carbonyloxymethyl)-4-pyridon-1-yl]-6-nitroquinoxaline-2-carboxylate

4-Chloropyridine

4-chloro-3-(hydroxymethyl)pyridine

2-nitro-4-fluoroaniline