(2Z,4E,6E)-2-(tert-Butyl-dimethyl-silanyloxymethyl)-5-methyl-7-(2,6,6-trimethyl-cyclohex-1-enyl)-hepta-2,4,6-trienal

Base Information

Chemical Name:(2Z,4E,6E)-2-(tert-Butyl-dimethyl-silanyloxymethyl)-5-methyl-7-(2,6,6-trimethyl-cyclohex-1-enyl)-hepta-2,4,6-trienal
CAS No.:99213-65-7
Molecular Formula:C₂₄H₄₀O₂Si
Molecular Weight:388.666
Hs Code.:

Synonyms:(2Z,4E,6E)-2-(tert-Butyl-dimethyl-silanyloxymethyl)-5-methyl-7-(2,6,6-trimethyl-cyclohex-1-enyl)-hepta-2,4,6-trienal

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Chemical Property of (2Z,4E,6E)-2-(tert-Butyl-dimethyl-silanyloxymethyl)-5-methyl-7-(2,6,6-trimethyl-cyclohex-1-enyl)-hepta-2,4,6-trienal

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Technology Process of (2Z,4E,6E)-2-(tert-Butyl-dimethyl-silanyloxymethyl)-5-methyl-7-(2,6,6-trimethyl-cyclohex-1-enyl)-hepta-2,4,6-trienal

There total 3 articles about (2Z,4E,6E)-2-(tert-Butyl-dimethyl-silanyloxymethyl)-5-methyl-7-(2,6,6-trimethyl-cyclohex-1-enyl)-hepta-2,4,6-trienal which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 88.0%

: 18162-48-6
tert-butyldimethylsilyl chloride

: 87927-37-5
(2Z,4E,6E)-2-Hydroxymethyl-5-methyl-7-(2,6,6-trimethyl-cyclohex-1-enyl)-hepta-2,4,6-trienal

: 99213-65-7
(2Z,4E,6E)-2-(tert-Butyl-dimethyl-silanyloxymethyl)-5-methyl-7-(2,6,6-trimethyl-cyclohex-1-enyl)-hepta-2,4,6-trienal

Guidance literature:: With 1H-imidazole; In N,N-dimethyl-formamide; at 25 ℃; for 2h;
DOI:10.1021/ja00311a050

Reference yield:

: 3917-41-7
(2E,4E)-3-methyl-5-(2,6,6-trimethyl-1-cyclohexen-1-yl)-2,4-pentadienal

: 99213-65-7
(2Z,4E,6E)-2-(tert-Butyl-dimethyl-silanyloxymethyl)-5-methyl-7-(2,6,6-trimethyl-cyclohex-1-enyl)-hepta-2,4,6-trienal

Guidance literature:: Multi-step reaction with 3 steps

1: 85 percent / NaH / tetrahydrofuran; hexamethylphosphoric acid triamide / 1 h / Ambient temperature

2: 1.) 1 M diisobutylaluminum hydride (DIBAL), ethyl acetate; 2.) water / 1.) hexane, -78 deg C, 30 min; 2.) rt., 3 h

3: 88 percent / imidazole / dimethylformamide / 2 h / 25 °C

With 1H-imidazole; water; sodium hydride; diisobutylaluminium hydride; ethyl acetate; In tetrahydrofuran; N,N,N,N,N,N-hexamethylphosphoric triamide; N,N-dimethyl-formamide;
DOI:10.1021/ja00311a050

Reference yield:

: 87927-36-4
(2E,4E,6E)-2-Cyano-5-methyl-7-(2,6,6-trimethyl-cyclohex-1-enyl)-hepta-2,4,6-trienoic acid ethyl ester

: 99213-65-7
(2Z,4E,6E)-2-(tert-Butyl-dimethyl-silanyloxymethyl)-5-methyl-7-(2,6,6-trimethyl-cyclohex-1-enyl)-hepta-2,4,6-trienal

Guidance literature:: Multi-step reaction with 2 steps

1: 1.) 1 M diisobutylaluminum hydride (DIBAL), ethyl acetate; 2.) water / 1.) hexane, -78 deg C, 30 min; 2.) rt., 3 h

2: 88 percent / imidazole / dimethylformamide / 2 h / 25 °C

With 1H-imidazole; water; diisobutylaluminium hydride; ethyl acetate; In N,N-dimethyl-formamide;
DOI:10.1021/ja00311a050