3-[(3-cyanopropyl)(phenylmethyl)amino-1(R)-methylpropyl]carbamic acid, 1,1-dimethylethyl ester

Base Information

Chemical Name:3-[(3-cyanopropyl)(phenylmethyl)amino-1(R)-methylpropyl]carbamic acid, 1,1-dimethylethyl ester
CAS No.:170367-71-2
Molecular Formula:C₂₀H₃₁N₃O₂
Molecular Weight:345.485
Hs Code.:

Synonyms:3-[(3-cyanopropyl)(phenylmethyl)amino-1(R)-methylpropyl]carbamic acid, 1,1-dimethylethyl ester

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Chemical Property of 3-[(3-cyanopropyl)(phenylmethyl)amino-1(R)-methylpropyl]carbamic acid, 1,1-dimethylethyl ester

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Technology Process of 3-[(3-cyanopropyl)(phenylmethyl)amino-1(R)-methylpropyl]carbamic acid, 1,1-dimethylethyl ester

There total 7 articles about 3-[(3-cyanopropyl)(phenylmethyl)amino-1(R)-methylpropyl]carbamic acid, 1,1-dimethylethyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 98.0%

: 628-20-6
4-Chlorobutyronitrile

: 170367-70-1
[1(R)-methyl-3-[(phenylmethyl)amino]propyl]carbamic acid, 1,1-dimethylethyl ester

: 170367-71-2
3-[(3-cyanopropyl)(phenylmethyl)amino-1(R)-methylpropyl]carbamic acid, 1,1-dimethylethyl ester

Guidance literature:: With sodium carbonate; potassium iodide; In butan-1-ol; for 20h; Heating;
DOI:10.1021/jm991043x

Reference yield:

: 24424-99-5
di-tert-butyl dicarbonate

: 170367-71-2
3-[(3-cyanopropyl)(phenylmethyl)amino-1(R)-methylpropyl]carbamic acid, 1,1-dimethylethyl ester

Guidance literature:: Multi-step reaction with 7 steps

1: 82 percent / tetrahydrofuran / 1 h / 20 °C

2: 86 percent / Et₃N / CH₂Cl₂ / 2 h / 20 °C

3: 70 percent / dimethylsulfoxide / 15 h / 40 - 45 °C

4: 96 percent / H₂; NH₃ / Raney Ni / ethanol / 15 h / 20 °C / 4500.36 Torr

5: 98 percent / 3 Angstroem molecular sieves / diethyl ether / 20 h / 20 °C

6: 86 percent / NaBH₄ / ethanol / 3 h / 10 °C

7: 98 percent / KI; Na₂CO₃ / butan-1-ol / 20 h / Heating

With sodium tetrahydroborate; 3 A molecular sieve; ammonia; hydrogen; sodium carbonate; triethylamine; potassium iodide; nickel; In tetrahydrofuran; diethyl ether; ethanol; dichloromethane; dimethyl sulfoxide; butan-1-ol; 1: tert-Butyloxycarbonylation / 2: Mesylation / 3: Substitution / 4: Catalytic hydrogenation / 5: Condensation / 6: Reduction / 7: Alkylation;
DOI:10.1021/jm991043x

Reference yield:

: 79069-13-9,127516-56-7,147252-84-4,106391-86-0
(R)-2-tertbutoxycarbonylamino-1-propanol

: 170367-71-2
3-[(3-cyanopropyl)(phenylmethyl)amino-1(R)-methylpropyl]carbamic acid, 1,1-dimethylethyl ester

Guidance literature:: Multi-step reaction with 6 steps

1: 86 percent / Et₃N / CH₂Cl₂ / 2 h / 20 °C

2: 70 percent / dimethylsulfoxide / 15 h / 40 - 45 °C

3: 96 percent / H₂; NH₃ / Raney Ni / ethanol / 15 h / 20 °C / 4500.36 Torr

4: 98 percent / 3 Angstroem molecular sieves / diethyl ether / 20 h / 20 °C

5: 86 percent / NaBH₄ / ethanol / 3 h / 10 °C

6: 98 percent / KI; Na₂CO₃ / butan-1-ol / 20 h / Heating

With sodium tetrahydroborate; 3 A molecular sieve; ammonia; hydrogen; sodium carbonate; triethylamine; potassium iodide; nickel; In diethyl ether; ethanol; dichloromethane; dimethyl sulfoxide; butan-1-ol; 1: Mesylation / 2: Substitution / 3: Catalytic hydrogenation / 4: Condensation / 5: Reduction / 6: Alkylation;
DOI:10.1021/jm991043x