N-(3,4-dichloro-phenyl)-N-ethyl-4-(1-methyl-piperidin-4-yl)-butyramide

Base Information

Chemical Name:N-(3,4-dichloro-phenyl)-N-ethyl-4-(1-methyl-piperidin-4-yl)-butyramide
CAS No.:1227850-53-4
Molecular Formula:C₁₈H₂₆Cl₂N₂O
Molecular Weight:357.323
Hs Code.:

Synonyms:N-(3,4-dichloro-phenyl)-N-ethyl-4-(1-methyl-piperidin-4-yl)-butyramide

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Chemical Property of N-(3,4-dichloro-phenyl)-N-ethyl-4-(1-methyl-piperidin-4-yl)-butyramide

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Technology Process of N-(3,4-dichloro-phenyl)-N-ethyl-4-(1-methyl-piperidin-4-yl)-butyramide

There total 5 articles about N-(3,4-dichloro-phenyl)-N-ethyl-4-(1-methyl-piperidin-4-yl)-butyramide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 87.0%

: 50-00-0,30525-89-4,61233-19-0
formaldehyd

: 1227850-50-1
N-(3,4-dichloro-phenyl)-N-ethyl-4-piperidin-4-yl-butyramide

: 1227850-53-4
N-(3,4-dichloro-phenyl)-N-ethyl-4-(1-methyl-piperidin-4-yl)-butyramide

Guidance literature:: formaldehyd; N-(3,4-dichloro-phenyl)-N-ethyl-4-piperidin-4-yl-butyramide; In dichloromethane; at 20 ℃; for 0.333333h;

With sodium tris(acetoxy)borohydride; In dichloromethane; at 20 ℃; for 15h;

Reference yield:

: 95-76-1
m,p-dichloroaniline

: 1227850-53-4
N-(3,4-dichloro-phenyl)-N-ethyl-4-(1-methyl-piperidin-4-yl)-butyramide

Guidance literature:: Multi-step reaction with 4 steps

1.1: 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; benzotriazol-1-ol / dichloromethane / 15 h / 20 °C

2.1: sodium hydride / tetrahydrofuran / 15 h / 20 °C

2.2: 20 °C

3.1: trifluoroacetic acid / dichloromethane / 2 h / 20 °C

4.1: 1,2-dichloro-ethane / 0.33 h / 20 °C

4.2: 15 h / 20 °C

4.3: 20 °C

With sodium hydride; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; trifluoroacetic acid; In tetrahydrofuran; dichloromethane; 1,2-dichloro-ethane;

Reference yield:

: 1242248-07-2
4-[3-(3,4-dichloro-phenylcarbamoyl)-propyl]-piperidine-1-carboxylic acid tert-butyl ester

: 1227850-53-4
N-(3,4-dichloro-phenyl)-N-ethyl-4-(1-methyl-piperidin-4-yl)-butyramide

Guidance literature:: Multi-step reaction with 3 steps

1.1: sodium hydride / tetrahydrofuran / 15 h / 20 °C

1.2: 20 °C

2.1: trifluoroacetic acid / dichloromethane / 2 h / 20 °C

3.1: 1,2-dichloro-ethane / 0.33 h / 20 °C

3.2: 15 h / 20 °C

3.3: 20 °C

With sodium hydride; trifluoroacetic acid; In tetrahydrofuran; dichloromethane; 1,2-dichloro-ethane;