1,1-dimethylethyl ({3-[(3-{bis[(5-chloro-2-thienyl)sulfonyl]amino}-4-cyano-1Hindazol-1-yl)methyl]phenyl}methyl)carbamate

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Chemical Name:1,1-dimethylethyl ({3-[(3-{bis[(5-chloro-2-thienyl)sulfonyl]amino}-4-cyano-1Hindazol-1-yl)methyl]phenyl}methyl)carbamate
CAS No.:1240518-58-4
Molecular Formula:C₂₉H₂₅Cl₂N₅O₆S₄
Molecular Weight:738.717
Hs Code.:

Synonyms:1,1-dimethylethyl ({3-[(3-{bis[(5-chloro-2-thienyl)sulfonyl]amino}-4-cyano-1Hindazol-1-yl)methyl]phenyl}methyl)carbamate

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Chemical Property of 1,1-dimethylethyl ({3-[(3-{bis[(5-chloro-2-thienyl)sulfonyl]amino}-4-cyano-1Hindazol-1-yl)methyl]phenyl}methyl)carbamate

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Technology Process of 1,1-dimethylethyl ({3-[(3-{bis[(5-chloro-2-thienyl)sulfonyl]amino}-4-cyano-1Hindazol-1-yl)methyl]phenyl}methyl)carbamate

There total 7 articles about 1,1-dimethylethyl ({3-[(3-{bis[(5-chloro-2-thienyl)sulfonyl]amino}-4-cyano-1Hindazol-1-yl)methyl]phenyl}methyl)carbamate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 96.0%

: 1240518-57-3
5-chloro-N-[(5-chloro-2-thienyl)sulfonyl]-N-(4-cyano-1H-indazol-3-yl)-2-thiophenesulfonamide

: 226070-69-5
1,1-dimethylethyl {[3-(hydroxymethyl)phenyl]methyl}carbamate

: 1240518-58-4
1,1-dimethylethyl ({3-[(3-{bis[(5-chloro-2-thienyl)sulfonyl]amino}-4-cyano-1Hindazol-1-yl)methyl]phenyl}methyl)carbamate

Guidance literature:: With di-isopropyl azodicarboxylate; triphenylphosphine; In tetrahydrofuran; at 60 ℃; for 1h;

Reference yield:

: 874-97-5
3-(hydroxymethyl)benzonitrile

: 1240518-58-4
1,1-dimethylethyl ({3-[(3-{bis[(5-chloro-2-thienyl)sulfonyl]amino}-4-cyano-1Hindazol-1-yl)methyl]phenyl}methyl)carbamate

Guidance literature:: Multi-step reaction with 2 steps

1: nickel dichloride; sodium tetrahydroborate / methanol; tetrahydrofuran / 3 h / 0 °C

2: triphenylphosphine; di-isopropyl azodicarboxylate / tetrahydrofuran / 1 h / 60 °C

With sodium tetrahydroborate; di-isopropyl azodicarboxylate; triphenylphosphine; nickel dichloride; In tetrahydrofuran; methanol; 2: |Mitsunobu Displacement;
DOI:10.1021/jm301572h

Reference yield:

: 65610-13-1
3-fluoro-1,2-benzenedicarbonitrile

: 1240518-58-4
1,1-dimethylethyl ({3-[(3-{bis[(5-chloro-2-thienyl)sulfonyl]amino}-4-cyano-1Hindazol-1-yl)methyl]phenyl}methyl)carbamate

Guidance literature:: Multi-step reaction with 5 steps

1: hydrazine hydrate / ethanol / 70 °C / Inert atmosphere

2: triethylamine; dmap / dichloromethane; acetonitrile / 0.5 h / Inert atmosphere

3: dichloromethane / 62 h / 45 °C / Inert atmosphere

4: trifluoroacetic acid / dichloromethane / 1.17 h

5: triphenylphosphine; di-isopropyl azodicarboxylate / tetrahydrofuran / 1 h / 60 °C

With dmap; di-isopropyl azodicarboxylate; hydrazine hydrate; triethylamine; triphenylphosphine; trifluoroacetic acid; In tetrahydrofuran; ethanol; dichloromethane; acetonitrile; 5: |Mitsunobu Displacement;
DOI:10.1021/jm301572h