4-HYDROXY-4-PHENYL-BUTYRIC ACID

Base Information

• Chemical Name: 4-HYDROXY-4-PHENYL-BUTYRIC ACID
• CAS No.: 34674-93-6
• Molecular Formula: C₁₀H₁₂O₃
• Molecular Weight: 180.203
• Mol file: 34674-93-6.mol

Synonyms:4-hydroxy-4-phenylbutanoic acid

Chemical Property of 4-HYDROXY-4-PHENYL-BUTYRIC ACID

Chemical Property:

Purity/Quality:

98%min ^*data from raw suppliers

4-Hydroxy-4-phenyl-butyricAcid ^*data from reagent suppliers

Safty Information:

• Hazard Codes: Xi

MSDS Files:

Useful:

Technology Process of 4-HYDROXY-4-PHENYL-BUTYRIC ACID

There total 26 articles about 4-HYDROXY-4-PHENYL-BUTYRIC ACID which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 76.0%

4,5-dihydro-5-phenyl-2(3H)-furanone (1008-76-0) → 4-hydroxy-4-phenylbutanoic acid (34674-93-6)

Guidance literature:

With sodium hydroxide; Ambient temperature;

DOI:10.1021/jm00378a005

Reference yield: 52.0%

(+/-)-4-hydroxy-4-phenylbutanenitrile (24241-74-5) → 4-hydroxy-4-phenylbutanoic acid (34674-93-6)

Guidance literature:

enzyme from Synechocystis sp. PCC 6803; In phosphate buffer; at 30 ℃; for 12h; pH=7.2;

DOI:10.1002/ejoc.200600699

Reference yield: 3.0%

3-benzoylpropionic acid methyl ester (25333-24-8) → 4,5-dihydro-5-phenyl-2(3H)-furanone (1008-76-0) + 4-hydroxy-4-phenylbutanoic acid (34674-93-6)

Guidance literature:

With hydrogen; Cp*Ir(OTf)[(S,S)-Msdpen]; In methanol; at 60 ℃; for 24h; under 7600.51 Torr; Product distribution / selectivity;

upstream raw materials:

diethyl ether

(1R,2S,5R)-2-isopropyl-5-methylcyclohexyl 4-oxopentanoate

3-benzoylacrylic acid

5-oxo-2-phenyl-tetrahydro-furan-3-carboxylic acid

Downstream raw materials:

4-Phenylbutyric acid

4-phenyl-4-acetoxybutanoic acid

4-<(tert-butyldimethylsilyl)oxy>-4-phenylbutanoic acid

(-)-(S)-5-phenyl-4,5-dihydrofuran-2(3H)-one

Refernces

• 1、 Wang, Jin,Guo, Yu,Li, Shouhu,Chen, Xuenian. "Sodium Aminodiboranate, a New Reagent for Chemoselective Reduction of Aldehydes and Ketones to Alcohols". supporting information. p. 1104 - 1108. Retrieved 2021/05/25.
• 2、 Mukherjee, Chandrani,Zhu, Dunming,Biehl, Edward R.,Parmar, Rajiv R.,Hua, Ling. "Enzymatic nitrile hydrolysis catalyzed by nitrilase ZmNIT2 from maize. An unprecedented β-hydroxy functionality enhanced amide formation". . p. 6150 - 6154. Retrieved 2007/10/03.