4-(5-methoxy-1-methyl-1H-indol-3-yl)-2-(methoxycarbonyl)-4-phenylbutanoic acid

Base Information

Chemical Name:4-(5-methoxy-1-methyl-1H-indol-3-yl)-2-(methoxycarbonyl)-4-phenylbutanoic acid
CAS No.:1315455-89-0
Molecular Formula:C₂₂H₂₃NO₅
Molecular Weight:381.428
Hs Code.:

Synonyms:4-(5-methoxy-1-methyl-1H-indol-3-yl)-2-(methoxycarbonyl)-4-phenylbutanoic acid

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Chemical Property of 4-(5-methoxy-1-methyl-1H-indol-3-yl)-2-(methoxycarbonyl)-4-phenylbutanoic acid

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Technology Process of 4-(5-methoxy-1-methyl-1H-indol-3-yl)-2-(methoxycarbonyl)-4-phenylbutanoic acid

There total 3 articles about 4-(5-methoxy-1-methyl-1H-indol-3-yl)-2-(methoxycarbonyl)-4-phenylbutanoic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 64.0%

: 2521-13-3
5-methoxy-N-methylindole

: 1034147-27-7
1,1-dicarboxylic acid monomethyl ester-2-phenylcyclopropane

: 1315455-89-0
4-(5-methoxy-1-methyl-1H-indol-3-yl)-2-(methoxycarbonyl)-4-phenylbutanoic acid

Guidance literature:: With 1,1,1,3',3',3'-hexafluoro-propanol; isopropyl alcohol; at 65 ℃; for 16h; Sealed tube; Inert atmosphere;
DOI:10.1021/acs.joc.8b00894

Reference yield: 58.0%

: 2521-13-3
5-methoxy-N-methylindole

: 97364-76-6,97364-77-7
methyl 2-phenylcyclopropane-1,1-dicarboxylate

: 1315455-89-0
4-(5-methoxy-1-methyl-1H-indol-3-yl)-2-(methoxycarbonyl)-4-phenylbutanoic acid

Guidance literature:: In acetonitrile; at 50 ℃; under 9750980 Torr; Sealed tube;
DOI:10.1021/ol201486x

Reference yield:

: 3709-20-4
dimethyl 2-phenyl-1,1-cyclopropanedicarboxylate

: 1315455-89-0
4-(5-methoxy-1-methyl-1H-indol-3-yl)-2-(methoxycarbonyl)-4-phenylbutanoic acid

Guidance literature:: Multi-step reaction with 2 steps

1.1: sodium hydroxide / methanol / 1.5 h

1.2: pH 2

2.1: acetonitrile / 50 °C / 9750980 Torr / Sealed tube

With sodium hydroxide; In methanol; acetonitrile;
DOI:10.1021/ol201486x