(S,E)-3-(4-methoxybenzyloxy)-7-(tritylthio)hept-4-en-1-ol

Base Information

Chemical Name:(S,E)-3-(4-methoxybenzyloxy)-7-(tritylthio)hept-4-en-1-ol
CAS No.:1027785-24-5
Molecular Formula:C₃₄H₃₆O₃S
Molecular Weight:524.724
Hs Code.:

Synonyms:(S,E)-3-(4-methoxybenzyloxy)-7-(tritylthio)hept-4-en-1-ol

Suppliers and Price of (S,E)-3-(4-methoxybenzyloxy)-7-(tritylthio)hept-4-en-1-ol

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of (S,E)-3-(4-methoxybenzyloxy)-7-(tritylthio)hept-4-en-1-ol

Chemical Property:

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Technology Process of (S,E)-3-(4-methoxybenzyloxy)-7-(tritylthio)hept-4-en-1-ol

There total 1 articles about (S,E)-3-(4-methoxybenzyloxy)-7-(tritylthio)hept-4-en-1-ol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 60.0%

: (2S,4S)-2-(4-methoxyphenyl)-4-[(E/Z)-4-(tritylthio)but-1-enyl]-1,3-dioxane

: 1027785-26-7
(S,Z)-3-(4-methoxybenzyloxy)-7-(tritylthio)hept-4-en-1-ol

: 1027785-24-5
(S,E)-3-(4-methoxybenzyloxy)-7-(tritylthio)hept-4-en-1-ol

Guidance literature:: With diisobutylaluminium hydride; In toluene; at 0 ℃; for 5h;
DOI:10.1039/b718310k

Reference yield: 88.0%

: 1027785-24-5
(S,E)-3-(4-methoxybenzyloxy)-7-(tritylthio)hept-4-en-1-ol

: 1027785-29-0
(S,E)-3-(4-methoxybenzyloxy)-7-(tritylthio)hept-4-enal

Guidance literature:: With sodium hydrogencarbonate; Dess-Martin periodane; In dichloromethane; at 20 ℃; for 1h;
DOI:10.1039/b718310k

Reference yield:

: 1027785-24-5
(S,E)-3-(4-methoxybenzyloxy)-7-(tritylthio)hept-4-en-1-ol

: 1075206-50-6
(7S,11R,14S,17R,18S,E)-18-(tert-butyldimethylsilyloxy)-7-hydroxy-17-isopropyl-11-methyl-9,12,15-trioxo-1,1,1-triphenyl-14-tritylthiomethyl-2-thia-10,13,16-triazaicos-5-en-20-oic acid

Guidance literature:: Multi-step reaction with 7 steps

1: sodium hydrogencarbonate; Dess-Martin periodane / dichloromethane / 1 h / 20 °C

2: sodium chlorite; sodium dihydrogenphosphate dihydrate / water; dimethyl sulfoxide / 0 - 20 °C

3: benzotriazol-1-yloxyl-tris-(pyrrolidino)-phosphonium hexafluorophosphate; N-ethyl-N,N-diisopropylamine / acetonitrile / 2 h / 20 °C / Inert atmosphere

4: lithium hydroxide / methanol / 3 h / 20 °C

5: 1-hydroxy-7-aza-benzotriazole; N-ethyl-N,N-diisopropylamine; HATU / dichloromethane / 2 h / -30 °C / Inert atmosphere

6: 2,3-dicyano-5,6-dichloro-p-benzoquinone / dichloromethane; water / 3 h / 20 °C

7: morpholine; tetrakis(triphenylphosphine) palladium⁽⁰⁾ / tetrahydrofuran / 0.5 h / 20 °C / Inert atmosphere

With morpholine; sodium chlorite; tetrakis(triphenylphosphine) palladium⁽⁰⁾; 1-hydroxy-7-aza-benzotriazole; sodium dihydrogenphosphate dihydrate; benzotriazol-1-yloxyl-tris-(pyrrolidino)-phosphonium hexafluorophosphate; sodium hydrogencarbonate; Dess-Martin periodane; N-ethyl-N,N-diisopropylamine; HATU; 2,3-dicyano-5,6-dichloro-p-benzoquinone; lithium hydroxide; In tetrahydrofuran; methanol; dichloromethane; water; dimethyl sulfoxide; acetonitrile; 1: Dess-Martin oxidation / 2: Pinnick oxidation;
DOI:10.3987/COM-07-S(N)5