(R)-methyl 2-[(S,E)-3-(4-methoxybenzyloxy)-7-(tritylthio)hept-4-enamido]propanoate

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Chemical Name:(R)-methyl 2-[(S,E)-3-(4-methoxybenzyloxy)-7-(tritylthio)hept-4-enamido]propanoate
CAS No.:1027785-33-6
Molecular Formula:C₃₈H₄₁NO₅S
Molecular Weight:623.813
Hs Code.:

Synonyms:(R)-methyl 2-[(S,E)-3-(4-methoxybenzyloxy)-7-(tritylthio)hept-4-enamido]propanoate

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Chemical Property of (R)-methyl 2-[(S,E)-3-(4-methoxybenzyloxy)-7-(tritylthio)hept-4-enamido]propanoate

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Technology Process of (R)-methyl 2-[(S,E)-3-(4-methoxybenzyloxy)-7-(tritylthio)hept-4-enamido]propanoate

There total 4 articles about (R)-methyl 2-[(S,E)-3-(4-methoxybenzyloxy)-7-(tritylthio)hept-4-enamido]propanoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 90.0%

: 1027785-31-4
(S,E)-3-(4-methoxybenzyloxy)-7-(tritylthio)hept-4-enoic acid

: 7625-53-8,10065-72-2,21705-13-5
D-alanine methyl ester

: 1027785-33-6
(R)-methyl 2-[(S,E)-3-(4-methoxybenzyloxy)-7-(tritylthio)hept-4-enamido]propanoate

Guidance literature:: With benzotriazol-1-yloxyl-tris-(pyrrolidino)-phosphonium hexafluorophosphate; diisopropylamine; In acetonitrile; at 20 ℃; for 2h;
DOI:10.1039/b718310k

Reference yield:

: 1027785-29-0
(S,E)-3-(4-methoxybenzyloxy)-7-(tritylthio)hept-4-enal

: 1027785-33-6
(R)-methyl 2-[(S,E)-3-(4-methoxybenzyloxy)-7-(tritylthio)hept-4-enamido]propanoate

Guidance literature:: Multi-step reaction with 2 steps

1: sodium chlorite; sodium dihydrogenphosphate dihydrate / water; dimethyl sulfoxide / 0 - 20 °C

2: benzotriazol-1-yloxyl-tris-(pyrrolidino)-phosphonium hexafluorophosphate; N-ethyl-N,N-diisopropylamine / acetonitrile / 2 h / 20 °C / Inert atmosphere

With sodium chlorite; sodium dihydrogenphosphate dihydrate; benzotriazol-1-yloxyl-tris-(pyrrolidino)-phosphonium hexafluorophosphate; N-ethyl-N,N-diisopropylamine; In water; dimethyl sulfoxide; acetonitrile; 1: Pinnick oxidation;
DOI:10.3987/COM-07-S(N)5

Reference yield:

: 1027785-24-5
(S,E)-3-(4-methoxybenzyloxy)-7-(tritylthio)hept-4-en-1-ol

: 1027785-33-6
(R)-methyl 2-[(S,E)-3-(4-methoxybenzyloxy)-7-(tritylthio)hept-4-enamido]propanoate

Guidance literature:: Multi-step reaction with 3 steps

1: sodium hydrogencarbonate; Dess-Martin periodane / dichloromethane / 1 h / 20 °C

2: sodium chlorite; sodium dihydrogenphosphate dihydrate / water; dimethyl sulfoxide / 0 - 20 °C

3: benzotriazol-1-yloxyl-tris-(pyrrolidino)-phosphonium hexafluorophosphate; N-ethyl-N,N-diisopropylamine / acetonitrile / 2 h / 20 °C / Inert atmosphere

With sodium chlorite; sodium dihydrogenphosphate dihydrate; benzotriazol-1-yloxyl-tris-(pyrrolidino)-phosphonium hexafluorophosphate; sodium hydrogencarbonate; Dess-Martin periodane; N-ethyl-N,N-diisopropylamine; In dichloromethane; water; dimethyl sulfoxide; acetonitrile; 1: Dess-Martin oxidation / 2: Pinnick oxidation;
DOI:10.3987/COM-07-S(N)5