(R)-2-[(S,E)-3-(4-methoxybenzyloxy)-7-(tritylthio)hept-4-enamido]propanoic acid

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Chemical Name:(R)-2-[(S,E)-3-(4-methoxybenzyloxy)-7-(tritylthio)hept-4-enamido]propanoic acid
CAS No.:1027785-35-8
Molecular Formula:C₃₇H₃₉NO₅S
Molecular Weight:609.786
Hs Code.:

Synonyms:(R)-2-[(S,E)-3-(4-methoxybenzyloxy)-7-(tritylthio)hept-4-enamido]propanoic acid

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Chemical Property of (R)-2-[(S,E)-3-(4-methoxybenzyloxy)-7-(tritylthio)hept-4-enamido]propanoic acid

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Technology Process of (R)-2-[(S,E)-3-(4-methoxybenzyloxy)-7-(tritylthio)hept-4-enamido]propanoic acid

There total 5 articles about (R)-2-[(S,E)-3-(4-methoxybenzyloxy)-7-(tritylthio)hept-4-enamido]propanoic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 98.0%

: 1027785-33-6
(R)-methyl 2-[(S,E)-3-(4-methoxybenzyloxy)-7-(tritylthio)hept-4-enamido]propanoate

: 1027785-35-8
(R)-2-[(S,E)-3-(4-methoxybenzyloxy)-7-(tritylthio)hept-4-enamido]propanoic acid

Guidance literature:: With lithium hydroxide; In methanol; at 20 ℃; for 3h;
DOI:10.1039/b718310k

Reference yield:

: (2S,4S)-2-(4-methoxyphenyl)-4-[(E/Z)-4-(tritylthio)but-1-enyl]-1,3-dioxane

: 1027785-35-8
(R)-2-[(S,E)-3-(4-methoxybenzyloxy)-7-(tritylthio)hept-4-enamido]propanoic acid

Guidance literature:: Multi-step reaction with 5 steps

1: diisobutylaluminium hydride / toluene / 5 h / 0 °C / Inert atmosphere

2: sodium hydrogencarbonate; Dess-Martin periodane / dichloromethane / 1 h / 20 °C

3: sodium chlorite; sodium dihydrogenphosphate dihydrate / water; dimethyl sulfoxide / 0 - 20 °C

4: benzotriazol-1-yloxyl-tris-(pyrrolidino)-phosphonium hexafluorophosphate; N-ethyl-N,N-diisopropylamine / acetonitrile / 2 h / 20 °C / Inert atmosphere

5: lithium hydroxide / methanol / 3 h / 20 °C

With sodium chlorite; sodium dihydrogenphosphate dihydrate; benzotriazol-1-yloxyl-tris-(pyrrolidino)-phosphonium hexafluorophosphate; diisobutylaluminium hydride; sodium hydrogencarbonate; Dess-Martin periodane; N-ethyl-N,N-diisopropylamine; lithium hydroxide; In methanol; dichloromethane; water; dimethyl sulfoxide; toluene; acetonitrile; 2: Dess-Martin oxidation / 3: Pinnick oxidation;
DOI:10.3987/COM-07-S(N)5

Reference yield:

: 1027785-29-0
(S,E)-3-(4-methoxybenzyloxy)-7-(tritylthio)hept-4-enal

: 1027785-35-8
(R)-2-[(S,E)-3-(4-methoxybenzyloxy)-7-(tritylthio)hept-4-enamido]propanoic acid

Guidance literature:: Multi-step reaction with 3 steps

1: sodium chlorite; sodium dihydrogenphosphate dihydrate / water; dimethyl sulfoxide / 0 - 20 °C

2: benzotriazol-1-yloxyl-tris-(pyrrolidino)-phosphonium hexafluorophosphate; N-ethyl-N,N-diisopropylamine / acetonitrile / 2 h / 20 °C / Inert atmosphere

3: lithium hydroxide / methanol / 3 h / 20 °C

With sodium chlorite; sodium dihydrogenphosphate dihydrate; benzotriazol-1-yloxyl-tris-(pyrrolidino)-phosphonium hexafluorophosphate; N-ethyl-N,N-diisopropylamine; lithium hydroxide; In methanol; water; dimethyl sulfoxide; acetonitrile; 1: Pinnick oxidation;
DOI:10.3987/COM-07-S(N)5