(+/-)-7-chloro-8-methoxy-3-(6-aminohexyl)-1-phenyl-2,3,4,5-tetrahydro-1H-3-benzazepine

Base Information

Chemical Name:(+/-)-7-chloro-8-methoxy-3-(6-aminohexyl)-1-phenyl-2,3,4,5-tetrahydro-1H-3-benzazepine
CAS No.:171285-49-7
Molecular Formula:C₂₃H₃₁ClN₂O
Molecular Weight:386.965
Hs Code.:

Synonyms:(+/-)-7-chloro-8-methoxy-3-(6-aminohexyl)-1-phenyl-2,3,4,5-tetrahydro-1H-3-benzazepine

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Chemical Property of (+/-)-7-chloro-8-methoxy-3-(6-aminohexyl)-1-phenyl-2,3,4,5-tetrahydro-1H-3-benzazepine

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Technology Process of (+/-)-7-chloro-8-methoxy-3-(6-aminohexyl)-1-phenyl-2,3,4,5-tetrahydro-1H-3-benzazepine

There total 8 articles about (+/-)-7-chloro-8-methoxy-3-(6-aminohexyl)-1-phenyl-2,3,4,5-tetrahydro-1H-3-benzazepine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 85.0%

: 1026715-22-9
6-Amino-1-(7-chloro-8-methoxy-1-phenyl-1,2,4,5-tetrahydro-benzo[d]azepin-3-yl)-hexan-1-one

: 171285-49-7
(+/-)-7-chloro-8-methoxy-3-(6-aminohexyl)-1-phenyl-2,3,4,5-tetrahydro-1H-3-benzazepine

Guidance literature:: With lithium aluminium tetrahydride; sulfuric acid; In tetrahydrofuran; for 2h; Ambient temperature;
DOI:10.1021/jm00021a018

Reference yield:

: 7569-87-1
3-chloro-4-methoxyphenethylamine

: 171285-49-7
(+/-)-7-chloro-8-methoxy-3-(6-aminohexyl)-1-phenyl-2,3,4,5-tetrahydro-1H-3-benzazepine

Guidance literature:: Multi-step reaction with 5 steps

1: 50 percent / tetrahydrofuran / 18 h / Heating

2: 95 percent / 99percent CF₃COOH, 99percent CH₃SO₃H / 18 h / Heating

3: 1.) 1-hydroxybenzotriazole hydrate, dicylohexylcarbodiimide, 2.) Et₃N / 1.) DMF, 3 h, 2.) DMF, RT, 48 h

4: 79 percent / ISi(Me)3 / acetonitrile / 0.5 h / Ambient temperature

5: 85 percent / LiAlH₄, 98percent H₂SO₄ / tetrahydrofuran / 2 h / Ambient temperature

With lithium aluminium tetrahydride; methanesulfonic acid; trimethylsilyl iodide; sulfuric acid; 1-hydroxybenzotriazol-hydrate; triethylamine; dicyclohexyl-carbodiimide; trifluoroacetic acid; In tetrahydrofuran; acetonitrile;
DOI:10.1021/jm00021a018

Reference yield:

: 1947-00-8
6-(benzyloxycarbonylamino)hexanoic acid

: 171285-49-7
(+/-)-7-chloro-8-methoxy-3-(6-aminohexyl)-1-phenyl-2,3,4,5-tetrahydro-1H-3-benzazepine

Guidance literature:: Multi-step reaction with 3 steps

1: 1.) 1-hydroxybenzotriazole hydrate, dicylohexylcarbodiimide, 2.) Et₃N / 1.) DMF, 3 h, 2.) DMF, RT, 48 h

2: 79 percent / ISi(Me)3 / acetonitrile / 0.5 h / Ambient temperature

3: 85 percent / LiAlH₄, 98percent H₂SO₄ / tetrahydrofuran / 2 h / Ambient temperature

With lithium aluminium tetrahydride; trimethylsilyl iodide; sulfuric acid; 1-hydroxybenzotriazol-hydrate; triethylamine; dicyclohexyl-carbodiimide; In tetrahydrofuran; acetonitrile;
DOI:10.1021/jm00021a018