2-methoxy-3-O-benzylestradiol 17-O-(N,N-dimethyl)sulfamate

Base Information

Chemical Name:2-methoxy-3-O-benzylestradiol 17-O-(N,N-dimethyl)sulfamate
CAS No.:923029-67-8
Molecular Formula:C₂₈H₃₇NO₅S
Molecular Weight:499.671
Hs Code.:

Synonyms:2-methoxy-3-O-benzylestradiol 17-O-(N,N-dimethyl)sulfamate

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Chemical Property of 2-methoxy-3-O-benzylestradiol 17-O-(N,N-dimethyl)sulfamate

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Technology Process of 2-methoxy-3-O-benzylestradiol 17-O-(N,N-dimethyl)sulfamate

There total 4 articles about 2-methoxy-3-O-benzylestradiol 17-O-(N,N-dimethyl)sulfamate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 94.0%

: 923029-65-6
2-methoxy-3-benzyloxyestra-1,3,5(10)-trien-17β-yl sulfamate

: 74-88-4
methyl iodide

: 923029-67-8
2-methoxy-3-O-benzylestradiol 17-O-(N,N-dimethyl)sulfamate

Guidance literature:: With sodium hydride; In N,N-dimethyl-formamide; at 20 ℃; for 16h;
DOI:10.1021/jm060705x

Reference yield:

: 362-07-2
2-Methoxyestradiol

: 923029-67-8
2-methoxy-3-O-benzylestradiol 17-O-(N,N-dimethyl)sulfamate

Guidance literature:: Multi-step reaction with 3 steps

1: 86 percent / K₂CO₃ / ethanol / 8 h / Heating

2: 79 percent / H₂NSO₂Cl / N,N-dimethyl-acetamide / 3 h / 20 °C

3: 94 percent / NaH / dimethylformamide / 16 h / 20 °C

With sulphamoyl chloride; sodium hydride; potassium carbonate; In ethanol; N,N-dimethyl acetamide; N,N-dimethyl-formamide;
DOI:10.1021/jm060705x

Reference yield:

: 100-39-0
benzyl bromide

: 923029-67-8
2-methoxy-3-O-benzylestradiol 17-O-(N,N-dimethyl)sulfamate

Guidance literature:: Multi-step reaction with 3 steps

1: 86 percent / K₂CO₃ / ethanol / 8 h / Heating

2: 79 percent / H₂NSO₂Cl / N,N-dimethyl-acetamide / 3 h / 20 °C

3: 94 percent / NaH / dimethylformamide / 16 h / 20 °C

With sulphamoyl chloride; sodium hydride; potassium carbonate; In ethanol; N,N-dimethyl acetamide; N,N-dimethyl-formamide;
DOI:10.1021/jm060705x