6-(4-fluorophenyl)-3-{[4-(1H-2-methylimidazo[4.5-c]pyrid-1-yl)piperidin-1-yl]sulfonyl}indole-1-carboxylic acid t-butyl ester

Base Information

Chemical Name:6-(4-fluorophenyl)-3-{[4-(1H-2-methylimidazo[4.5-c]pyrid-1-yl)piperidin-1-yl]sulfonyl}indole-1-carboxylic acid t-butyl ester
CAS No.:183283-57-0
Molecular Formula:C₃₁H₃₂FN₅O₄S
Molecular Weight:589.691
Hs Code.:

Synonyms:6-(4-fluorophenyl)-3-{[4-(1H-2-methylimidazo[4.5-c]pyrid-1-yl)piperidin-1-yl]sulfonyl}indole-1-carboxylic acid t-butyl ester

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Chemical Property of 6-(4-fluorophenyl)-3-{[4-(1H-2-methylimidazo[4.5-c]pyrid-1-yl)piperidin-1-yl]sulfonyl}indole-1-carboxylic acid t-butyl ester

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Technology Process of 6-(4-fluorophenyl)-3-{[4-(1H-2-methylimidazo[4.5-c]pyrid-1-yl)piperidin-1-yl]sulfonyl}indole-1-carboxylic acid t-butyl ester

There total 11 articles about 6-(4-fluorophenyl)-3-{[4-(1H-2-methylimidazo[4.5-c]pyrid-1-yl)piperidin-1-yl]sulfonyl}indole-1-carboxylic acid t-butyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 72.0%

: CHCl₃ -methanol

: 183283-33-2
1-tert-butoxycarbonyl-6-(4-fluorophenyl)indole-3-sulfonyl chloride

: 183283-57-0
6-(4-fluorophenyl)-3-{[4-(1H-2-methylimidazo[4.5-c]pyrid-1-yl)piperidin-1-yl]sulfonyl}indole-1-carboxylic acid t-butyl ester

Guidance literature:: With triethylamine; In tetrahydrofuran;

Reference yield:

: 58859-46-4
ethyl 4-aminopiperidine-1-carboxylate

: 183283-57-0
6-(4-fluorophenyl)-3-{[4-(1H-2-methylimidazo[4.5-c]pyrid-1-yl)piperidin-1-yl]sulfonyl}indole-1-carboxylic acid t-butyl ester

Guidance literature:: Multi-step reaction with 5 steps

1: acetonitrile / 40 h / Heating

2: H₂ / 10percent Pd/C / ethanol / 760 Torr

3: 3.7 g / AcOH / 70 h / Heating

4: 2.07 g / aq. KOH / ethanol / 72 h / Heating

5: 141 mg / Et₃N / tetrahydrofuran / 48 h / Ambient temperature

With potassium hydroxide; hydrogen; acetic acid; triethylamine; palladium on activated charcoal; In tetrahydrofuran; ethanol; acetonitrile;
DOI:10.1021/jm970389+

Reference yield:

: 1796-84-5
4-ethoxy-3-nitropyridine

: 183283-57-0
6-(4-fluorophenyl)-3-{[4-(1H-2-methylimidazo[4.5-c]pyrid-1-yl)piperidin-1-yl]sulfonyl}indole-1-carboxylic acid t-butyl ester

Guidance literature:: Multi-step reaction with 5 steps

1: acetonitrile / 40 h / Heating

2: H₂ / 10percent Pd/C / ethanol / 760 Torr

3: 3.7 g / AcOH / 70 h / Heating

4: 2.07 g / aq. KOH / ethanol / 72 h / Heating

5: 141 mg / Et₃N / tetrahydrofuran / 48 h / Ambient temperature

With potassium hydroxide; hydrogen; acetic acid; triethylamine; palladium on activated charcoal; In tetrahydrofuran; ethanol; acetonitrile;
DOI:10.1021/jm970389+