1796-84-5

Usage

Uses

Used in Pharmaceutical Industry:
4-Ethoxy-3-nitropyridine is used as a synthetic intermediate for the development of various pharmaceutical compounds. Its unique structure allows for the creation of a wide range of medications, contributing to the advancement of healthcare and treatment options.
Used in Agricultural Industry:
In the agricultural sector, 4-Ethoxy-3-nitropyridine is utilized as a precursor in the synthesis of agrochemicals. Its role in developing effective pesticides and other agricultural products helps improve crop protection and yield.
Used in Research and Development:
4-Ethoxy-3-nitropyridine is employed as a key component in research and development applications, where it aids in the production of various chemical products. Its versatility and reactivity make it an invaluable asset in scientific exploration and innovation.

InChI:InChI=1/C7H8N2O3/c1-2-12-7-3-4-8-5-6(7)9(10)11/h3-5H,2H2,1H3

Upstream product

• 141-52-6 sodium ethanolate 
• 54079-68-4 3-nitro-4-chloropyridine hydrochloride 
• 13091-23-1 4-chloro-3-nitropyridine 
• 64-17-5 ethanol 
• 94602-04-7 4-ethoxy-3-nitropyridine hydrochloride 
• 5435-54-1 4-hydroxy-3-nitropyridine 
• 3454-03-3 nitrate 4-hydroxypyridine 
• 33399-46-1 4-ethoxypyridine 

Downstream Products

• 1633-43-8 4-ethoxypyridin-3-ylamine 
• 183283-81-0 1-Dimethylcarbamoyl-3-{4-[(3-nitro-pyridin-4-ylamino)-methyl]-cyclohexanecarbonyl}-1H-indole-4-carboxylic acid methyl ester 
• 183283-82-1 3-{4-[(3-Amino-pyridin-4-ylamino)-methyl]-cyclohexanecarbonyl}-1-dimethylcarbamoyl-1H-indole-4-carboxylic acid methyl ester 
• 183283-58-1 6-(4-fluorophenyl)-3-{[4-(1H-2-methylimidazo[4.5-c]pyrid-1-yl)piperidin-1-yl]sulfonyl}indole 
• 183283-65-0 1-(2-{4-[6-(4-Fluoro-phenyl)-1H-indole-3-sulfonyl]-piperazin-1-yl}-ethyl)-2-methyl-1H-imidazo[4,5-c]pyridine 
• 183283-57-0 6-(4-fluorophenyl)-3-{[4-(1H-2-methylimidazo[4.5-c]pyrid-1-yl)piperidin-1-yl]sulfonyl}indole-1-carboxylic acid t-butyl ester 
• 183283-64-9 6-(4-Fluoro-phenyl)-3-{4-[2-(2-methyl-imidazo[4,5-c]pyridin-1-yl)-ethyl]-piperazine-1-sulfonyl}-indole-1-carboxylic acid tert-butyl ester 
• 14060-62-9 2-(2'-Pyridyl)imidazo<4,5-c>pyridine 
• 170499-52-2 3-[(4-(N-3-nitropyrid-4-yl)aminomethyl)phenylsulfonyl]indole 
• 1050589-14-4 2-benzenesulfonylmethyl-4-ethoxy-5-nitropyridine 
• 1050589-10-0 2-benzenesulfonylmethyl-4-ethoxy-3-nitropyridine 
• 1050589-63-3 (1-nitro-2-naphthyl)methyl phenyl sulfone 
• 89303-10-6 5-chloro-2-nitrobenzyl phenyl sulfone 

Relevant academic research and scientific papers

Synthesis and structure of dipyrido-1,4-dithiins

Synthesis, properties and reactions of two isomeric dipyrido-1,4-dithiins of the C2h and C2v symmetry are described. Their structure determination and identification are based on spectroscopic methods (1H and 13C NMR, HETCOR, gHMBC and MS), physical properties (mp and Rf), the 1,4-dithiin ring opening reactions and finally X-Ray analysis. A very unusual type of the Smiles rearrangement (S→S, the pyridyl group migrates from one sulfur atom to another) during the 1,4-dithiin ring opening with sodium methanethiolate enabling isomerization of dithiin with the C2h symmetry to dithiin with the C2v symmetry is found.

CANCER TREATMENT METHOD

The present invention relates to a method of treating cancer in a mammal and to pharmaceutical combinations useful in such treatment. In particular, the method relates to a cancer treatment method that includes administering an erb family inhibitor and a PI3K and/or Akt inhibitor to a mammal suffering from a cancer.

Potential inhibitors of S-adenosylmethionine-dependent methyltransferases. 8. Molecular dissections of carbocyclic 3-deazaadenosine as inhibitors of S-adenosylhomocysteine hydrolase

A series of 9-(hydroxyalkyl)-3-deazaadenines, which are analogues of the carbocyclic derivative of 3-deazaadenosine (3-deaza-C-Adpo), were synthesized. The analogues were tested as inhibitors of bovine liver S-adenosyl-L-homocysteine (AdoHcy) hydrolase (EC 3.3.1.1) and as inhibitors of vaccinia virus (WR) replication in clone 929 mouse L cells and the results were compared to those observed for the parent compound, 3-deaza-C-Ado. 4-Amino-1-(2,3-dihydroxy-1-propyl)imidazo[4,5-c]pyridine (14), the analogue which included the 1'-, 2'- and 3'-carbons of 3-deaza-C-Ado, was the most active inhibitor toward purified AdoHcy hydrolase. The inhibitory effect of 14 (K(i) = 768 nM) on AdoHcy hydrolase was significantly less than that observed for 3-deaza-C-Ado (K(i) = 4 nM). Analogue 14 also exhibited inhibitory activity against vaccinia virus replication, but the activity was less than that observed with 3-deaza-C-Ado. 4-Amino-1-(4-hydroxy-1-butyl)imidazo[4,5-c]pyridine (15) showed little or no inhibitory activity toward AdoHcY hydrolase, but it did exhibit antiviral effects comparable to 14. These results suggest that 3-deaza-C-Ado and analogue 14 may be producing their antiviral effects by altering a critical viral methylation (e.g., methylation of the 5'-cap of viral mRNA), whereas analogue 15 may be acting through an alternative mechanism.