6-(4-fluorophenyl)-3-{[4-(1H-2-methylimidazo[4.5-c]pyrid-1-yl)piperidin-1-yl]sulfonyl}indole

Base Information

Chemical Name:6-(4-fluorophenyl)-3-{[4-(1H-2-methylimidazo[4.5-c]pyrid-1-yl)piperidin-1-yl]sulfonyl}indole
CAS No.:183283-58-1
Molecular Formula:C₂₆H₂₄FN₅O₂S
Molecular Weight:489.573
Hs Code.:

Synonyms:6-(4-fluorophenyl)-3-{[4-(1H-2-methylimidazo[4.5-c]pyrid-1-yl)piperidin-1-yl]sulfonyl}indole

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Chemical Property of 6-(4-fluorophenyl)-3-{[4-(1H-2-methylimidazo[4.5-c]pyrid-1-yl)piperidin-1-yl]sulfonyl}indole

Chemical Property:

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Technology Process of 6-(4-fluorophenyl)-3-{[4-(1H-2-methylimidazo[4.5-c]pyrid-1-yl)piperidin-1-yl]sulfonyl}indole

There total 12 articles about 6-(4-fluorophenyl)-3-{[4-(1H-2-methylimidazo[4.5-c]pyrid-1-yl)piperidin-1-yl]sulfonyl}indole which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 50.0%

: 183283-58-1
6-(4-fluorophenyl)-3-{[4-(1H-2-methylimidazo[4.5-c]pyrid-1-yl)piperidin-1-yl]sulfonyl}indole

Guidance literature:

Reference yield:

: 58859-46-4
ethyl 4-aminopiperidine-1-carboxylate

: 183283-58-1
6-(4-fluorophenyl)-3-{[4-(1H-2-methylimidazo[4.5-c]pyrid-1-yl)piperidin-1-yl]sulfonyl}indole

Guidance literature:: Multi-step reaction with 6 steps

1: acetonitrile / 40 h / Heating

2: H₂ / 10percent Pd/C / ethanol / 760 Torr

3: 3.7 g / AcOH / 70 h / Heating

4: 2.07 g / aq. KOH / ethanol / 72 h / Heating

5: 141 mg / Et₃N / tetrahydrofuran / 48 h / Ambient temperature

6: 51 mg / NaOMe, MeOH / tetrahydrofuran

With methanol; potassium hydroxide; hydrogen; sodium methylate; acetic acid; triethylamine; palladium on activated charcoal; In tetrahydrofuran; ethanol; acetonitrile;
DOI:10.1021/jm970389+

Reference yield:

: 1796-84-5
4-ethoxy-3-nitropyridine

: 183283-58-1
6-(4-fluorophenyl)-3-{[4-(1H-2-methylimidazo[4.5-c]pyrid-1-yl)piperidin-1-yl]sulfonyl}indole

Guidance literature:: Multi-step reaction with 6 steps

1: acetonitrile / 40 h / Heating

2: H₂ / 10percent Pd/C / ethanol / 760 Torr

3: 3.7 g / AcOH / 70 h / Heating

4: 2.07 g / aq. KOH / ethanol / 72 h / Heating

5: 141 mg / Et₃N / tetrahydrofuran / 48 h / Ambient temperature

6: 51 mg / NaOMe, MeOH / tetrahydrofuran

With methanol; potassium hydroxide; hydrogen; sodium methylate; acetic acid; triethylamine; palladium on activated charcoal; In tetrahydrofuran; ethanol; acetonitrile;
DOI:10.1021/jm970389+