(R)-2-{(S)-3-Methyl-3-[4-(2-methyl-quinolin-4-ylmethoxy)-phenyl]-2-oxo-pyrrolidin-1-yl}-propionic acid methyl ester

Base Information

Chemical Name:(R)-2-{(S)-3-Methyl-3-[4-(2-methyl-quinolin-4-ylmethoxy)-phenyl]-2-oxo-pyrrolidin-1-yl}-propionic acid methyl ester
CAS No.:478911-64-7
Molecular Formula:C₂₆H₂₈N₂O₄
Molecular Weight:432.519
Hs Code.:

Synonyms:(R)-2-{(S)-3-Methyl-3-[4-(2-methyl-quinolin-4-ylmethoxy)-phenyl]-2-oxo-pyrrolidin-1-yl}-propionic acid methyl ester

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Chemical Property of (R)-2-{(S)-3-Methyl-3-[4-(2-methyl-quinolin-4-ylmethoxy)-phenyl]-2-oxo-pyrrolidin-1-yl}-propionic acid methyl ester

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Technology Process of (R)-2-{(S)-3-Methyl-3-[4-(2-methyl-quinolin-4-ylmethoxy)-phenyl]-2-oxo-pyrrolidin-1-yl}-propionic acid methyl ester

There total 6 articles about (R)-2-{(S)-3-Methyl-3-[4-(2-methyl-quinolin-4-ylmethoxy)-phenyl]-2-oxo-pyrrolidin-1-yl}-propionic acid methyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 94.7%

: 478911-32-9
methyl (2R)-2-[(3S)-3-(4-hydroxyphenyl)-3-methyl-2-oxo-1-pyrrolidinyl]propanoate

: 4-chloromethyl-2-methylquinoline hydrochloride salt

: 478911-64-7
(R)-2-{(S)-3-Methyl-3-[4-(2-methyl-quinolin-4-ylmethoxy)-phenyl]-2-oxo-pyrrolidin-1-yl}-propionic acid methyl ester

Guidance literature:: With caesium carbonate; sodium iodide; In dimethyl sulfoxide; at 20 ℃; for 2.5h;
DOI:10.1021/jm0255670

Reference yield:

: 68641-16-7
(4-benzyloxy-phenyl)-acetic acid methyl ester

: 478911-64-7
(R)-2-{(S)-3-Methyl-3-[4-(2-methyl-quinolin-4-ylmethoxy)-phenyl]-2-oxo-pyrrolidin-1-yl}-propionic acid methyl ester

Guidance literature:: Multi-step reaction with 6 steps

1.1: sodium bis(trimethylsilyl)amide / tetrahydrofuran / 1 h / -78 °C

1.2: tetrahydrofuran / 2 h / -20 °C

2.1: sodium bis(trimethylsilyl)amide / tetrahydrofuran / 1 h / -78 °C

2.2: tetrahydrofuran / 2 h / -20 °C

3.1: ozone / CH₂Cl₂ / -78 °C

3.2: 44.6 g / triphenylphosphine / CH₂Cl₂ / 1 h / 20 °C

4.1: Zn; HOAc / Heating

5.1: 100 percent / H₂ / Pd(OH)2/C / methanol

6.1: 94.7 percent / cesium carbonate; sodium iodide / dimethylsulfoxide / 2.5 h / 20 °C

With hydrogen; sodium hexamethyldisilazane; caesium carbonate; ozone; acetic acid; sodium iodide; zinc; palladium dihydroxide; In tetrahydrofuran; methanol; dichloromethane; dimethyl sulfoxide;
DOI:10.1021/jm0255670

Reference yield:

: 89618-33-7
methyl 2-(4-benzyloxyphenyl)propionate

: 478911-64-7
(R)-2-{(S)-3-Methyl-3-[4-(2-methyl-quinolin-4-ylmethoxy)-phenyl]-2-oxo-pyrrolidin-1-yl}-propionic acid methyl ester

Guidance literature:: Multi-step reaction with 5 steps

1.1: sodium bis(trimethylsilyl)amide / tetrahydrofuran / 1 h / -78 °C

1.2: tetrahydrofuran / 2 h / -20 °C

2.1: ozone / CH₂Cl₂ / -78 °C

2.2: 44.6 g / triphenylphosphine / CH₂Cl₂ / 1 h / 20 °C

3.1: Zn; HOAc / Heating

4.1: 100 percent / H₂ / Pd(OH)2/C / methanol

5.1: 94.7 percent / cesium carbonate; sodium iodide / dimethylsulfoxide / 2.5 h / 20 °C

With hydrogen; sodium hexamethyldisilazane; caesium carbonate; ozone; acetic acid; sodium iodide; zinc; palladium dihydroxide; In tetrahydrofuran; methanol; dichloromethane; dimethyl sulfoxide;
DOI:10.1021/jm0255670