methyl (2R)-2-[(3S)-3-(4-hydroxyphenyl)-3-methyl-2-oxo-1-pyrrolidinyl]propanoate

Base Information

Chemical Name:methyl (2R)-2-[(3S)-3-(4-hydroxyphenyl)-3-methyl-2-oxo-1-pyrrolidinyl]propanoate
CAS No.:478911-32-9
Molecular Formula:C₁₅H₁₉NO₄
Molecular Weight:277.32
Hs Code.:

Synonyms:methyl (2R)-2-[(3S)-3-(4-hydroxyphenyl)-3-methyl-2-oxo-1-pyrrolidinyl]propanoate

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Chemical Property of methyl (2R)-2-[(3S)-3-(4-hydroxyphenyl)-3-methyl-2-oxo-1-pyrrolidinyl]propanoate

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Technology Process of methyl (2R)-2-[(3S)-3-(4-hydroxyphenyl)-3-methyl-2-oxo-1-pyrrolidinyl]propanoate

There total 5 articles about methyl (2R)-2-[(3S)-3-(4-hydroxyphenyl)-3-methyl-2-oxo-1-pyrrolidinyl]propanoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

: 223406-02-8
methyl (2R)-2-{(3S)-3-[4-(benzyloxy)phenyl]-3-methyl-2-oxo-1-pyrrolidinyl}propanoate

: 478911-32-9
methyl (2R)-2-[(3S)-3-(4-hydroxyphenyl)-3-methyl-2-oxo-1-pyrrolidinyl]propanoate

Guidance literature:: With hydrogen; palladium dihydroxide; In methanol;
DOI:10.1021/jm0255670

Reference yield:

: 68641-16-7
(4-benzyloxy-phenyl)-acetic acid methyl ester

: 478911-32-9
methyl (2R)-2-[(3S)-3-(4-hydroxyphenyl)-3-methyl-2-oxo-1-pyrrolidinyl]propanoate

Guidance literature:: Multi-step reaction with 5 steps

1.1: sodium bis(trimethylsilyl)amide / tetrahydrofuran / 1 h / -78 °C

1.2: tetrahydrofuran / 2 h / -20 °C

2.1: sodium bis(trimethylsilyl)amide / tetrahydrofuran / 1 h / -78 °C

2.2: tetrahydrofuran / 2 h / -20 °C

3.1: ozone / CH₂Cl₂ / -78 °C

3.2: 44.6 g / triphenylphosphine / CH₂Cl₂ / 1 h / 20 °C

4.1: Zn; HOAc / Heating

5.1: 100 percent / H₂ / Pd(OH)2/C / methanol

With hydrogen; sodium hexamethyldisilazane; ozone; acetic acid; zinc; palladium dihydroxide; In tetrahydrofuran; methanol; dichloromethane;
DOI:10.1021/jm0255670

Reference yield:

: 89618-33-7
methyl 2-(4-benzyloxyphenyl)propionate

: 478911-32-9
methyl (2R)-2-[(3S)-3-(4-hydroxyphenyl)-3-methyl-2-oxo-1-pyrrolidinyl]propanoate

Guidance literature:: Multi-step reaction with 4 steps

1.1: sodium bis(trimethylsilyl)amide / tetrahydrofuran / 1 h / -78 °C

1.2: tetrahydrofuran / 2 h / -20 °C

2.1: ozone / CH₂Cl₂ / -78 °C

2.2: 44.6 g / triphenylphosphine / CH₂Cl₂ / 1 h / 20 °C

3.1: Zn; HOAc / Heating

4.1: 100 percent / H₂ / Pd(OH)2/C / methanol

With hydrogen; sodium hexamethyldisilazane; ozone; acetic acid; zinc; palladium dihydroxide; In tetrahydrofuran; methanol; dichloromethane;
DOI:10.1021/jm0255670