(+/-)-trimethylsilyl β-(N-trimethylsilylamino)-β-(4-chlorophenyl)propionate

Base Information

Chemical Name:(+/-)-trimethylsilyl β-(N-trimethylsilylamino)-β-(4-chlorophenyl)propionate
CAS No.:566198-11-6
Molecular Formula:C₁₅H₂₆ClNO₂Si₂
Molecular Weight:344.001
Hs Code.:

Synonyms:(+/-)-trimethylsilyl β-(N-trimethylsilylamino)-β-(4-chlorophenyl)propionate

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Chemical Property of (+/-)-trimethylsilyl β-(N-trimethylsilylamino)-β-(4-chlorophenyl)propionate

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Technology Process of (+/-)-trimethylsilyl β-(N-trimethylsilylamino)-β-(4-chlorophenyl)propionate

There total 1 articles about (+/-)-trimethylsilyl β-(N-trimethylsilylamino)-β-(4-chlorophenyl)propionate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 61.0%

: 75-77-4
chloro-trimethyl-silane

: 19947-39-8,131690-61-4
3-amino-3-(4-chlorophenyl)propionic acid

: 566198-11-6
(+/-)-trimethylsilyl β-(N-trimethylsilylamino)-β-(4-chlorophenyl)propionate

Guidance literature:: chloro-trimethyl-silane; 3-amino-3-(4-chlorophenyl)propionic acid; In benzene; for 0.25h; Heating;

With triethylamine; In benzene; for 2h; Heating;
DOI:10.1007/s00706-002-0485-8

Reference yield: 36.0%

: 566198-11-6
(+/-)-trimethylsilyl β-(N-trimethylsilylamino)-β-(4-chlorophenyl)propionate

: 21161-20-6
1-tert-butoxycarbonyl-2-(4'-chloro)phenylazetidine

Guidance literature:: With ethylmagnesium bromide; In diethyl ether; at 0 - 20 ℃; for 14h;
DOI:10.1007/s00706-002-0485-8

Reference yield:

: 566198-11-6
(+/-)-trimethylsilyl β-(N-trimethylsilylamino)-β-(4-chlorophenyl)propionate

: 1-tert-butoxycarbonyl-2-(4'-chloro)phenylazetidine

Guidance literature:: Multi-step reaction with 2 steps

1.1: 36 percent / EtMgBr / diethyl ether / 14 h / 0 - 20 °C

2.1: BH₃*THF / tetrahydrofuran / 16 h / 20 °C / Heating

2.2: 53 percent / aq. HCl / tetrahydrofuran / 0.5 h / Heating

With borane-THF; ethylmagnesium bromide; In tetrahydrofuran; diethyl ether;
DOI:10.1007/s00706-002-0485-8