1-trimethylsilyl-1-propanol

Base Information

• Chemical Name: 1-trimethylsilyl-1-propanol
• CAS No.: 121386-64-9
• Molecular Formula: C6H16 O Si
• Molecular Weight: 0
• Mol file: 121386-64-9.mol

Synonyms:1-Propanol,1-(trimethylsilyl)-, (?à)-; (?à)-1-Trimethylsilyl-1-propanol;1-Trimethylsilyl-1-propanol

Chemical Property of 1-trimethylsilyl-1-propanol

Chemical Property:

• Vapor Pressure: 0.749mmHg at 25°C
• Boiling Point: 162.3°Cat760mmHg
• Flash Point: 53°C
• PSA: 20.23000
• Density: 0.82g/cm³
• LogP: 2.05460

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 1-trimethylsilyl-1-propanol

There total 6 articles about 1-trimethylsilyl-1-propanol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 86.0%

2,2-dimethyl-2-sila-3-pentanone (30608-90-3) → α-(trimethylsilyl)-n-propyl alcohol (121386-64-9)

Guidance literature:

With sodium tetrahydroborate; In ethanol; for 0.166667h; Heating;

DOI:10.1021/ja00355a025

Reference yield:

α-(trimethylsilyl)allyl alcohol (95061-68-0) → α-(trimethylsilyl)-n-propyl alcohol (121386-64-9)

Guidance literature:

With hydrogen; palladium on activated charcoal; In ethyl acetate; at 20 ℃; under 760.051 Torr;

DOI:10.1021/ol9909132

Reference yield:

1-(trimethylsilyl)-1-propene (17680-01-2) → α-(trimethylsilyl)-n-propyl alcohol (121386-64-9)

Guidance literature:

Multi-step reaction with 2 steps

1: ahnhydrous trimethylamine N-oxide / toluene / 1 h / 110 °C

2: BH₃*THF / 1) 0 deg C, 2) hydrolysis

With borane-THF; trimethylamine-N-oxide; In toluene;

DOI:10.1021/jo01306a006

upstream raw materials:

methanol

(Z)-trimethyl(prop-1-en-1-yl)silane

1-(trimethylsilyl)-1-propene

2,2-dimethyl-2-sila-3-pentanone