Technology Process of (3R,4R)-3-(4-benzyloxy-3-methoxybenzyl)-4-(4-methoxybenzyl)dihydrofuran-2(3H)-one
There total 5 articles about (3R,4R)-3-(4-benzyloxy-3-methoxybenzyl)-4-(4-methoxybenzyl)dihydrofuran-2(3H)-one which
guide to synthetic route it.
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synthetic route:
- Guidance literature:
-
With
palladium 10% on activated carbon; hydrogen;
In
ethanol;
for 0.5h;
DOI:10.1039/d1ob01653a
- Guidance literature:
-
Multi-step reaction with 4 steps
1.1: n-butyllithium / tetrahydrofuran / -78 - -20 °C / Inert atmosphere
1.2: 2 h / -78 °C / Inert atmosphere
2.1: nickel dichloride; sodium tetrahydroborate; methanol / tetrahydrofuran / 0 - 10 °C
2.2: 3 h / 20 °C / pH Ca. 8
3.1: lithium diisopropyl amide / tetrahydrofuran / 0.5 h / -78 °C / Inert atmosphere
3.2: 20 °C
4.1: palladium 10% on activated carbon; hydrogen / ethanol / 0.5 h
With
methanol; sodium tetrahydroborate; n-butyllithium; palladium 10% on activated carbon; hydrogen; nickel dichloride; lithium diisopropyl amide;
In
tetrahydrofuran; ethanol;
DOI:10.1039/d1ob01653a
- Guidance literature:
-
Multi-step reaction with 3 steps
1.1: phosphorus tribromide / diethyl ether / 0.33 h / 0 °C / Inert atmosphere
2.1: lithium diisopropyl amide / tetrahydrofuran / 0.5 h / -78 °C / Inert atmosphere
2.2: 20 °C
3.1: palladium 10% on activated carbon; hydrogen / ethanol / 0.5 h
With
palladium 10% on activated carbon; hydrogen; phosphorus tribromide; lithium diisopropyl amide;
In
tetrahydrofuran; diethyl ether; ethanol;
DOI:10.1039/d1ob01653a