23837-10-7

Upstream product

• 2403-58-9 4-methoxybenzaldehyde diethylacetal 
• 108-98-5 thiophenol 
• 5023-67-6 4-methoxybenzyl phenyl sulfide 
• 110-66-7 n-pentanethiol 
• 123-11-5 4-methoxy-benzaldehyde 
• 1078739-24-8 4-(4-methoxyphenyl)-1-tosyl-1H-1,2,3-triazole 
• 882-33-7 diphenyldisulfane 
• 100-53-8 phenylmethanethiol 
• 2186-92-7 p-Anisaldehyde dimethyl acetal 
• 40891-01-8 4-(dimorpholinomethyl)-1-methoxybenzene 

Downstream Products

• 5023-67-6 4-methoxybenzyl phenyl sulfide 
• 1316843-77-2 (3R,4R)-3-(4-benzyloxy-3-methoxybenzyl)-4-(4-methoxybenzyl)dihydrofuran-2(3H)-one 
• 1567359-97-0 1-(4-methoxyphenyl)-4-methyl-2-(triisopropylsiloxy)-1,3-pentadiene 
• 1567359-98-1 1-(4-methoxyphenyl)-4-methyl-2-(triisopropylsiloxy)-1,3-pentadiene 
• 94550-08-0 ((4-methoxyphenyl)methylenedisulfonyl)dibenzene 
• 13087-56-4 1-(hepta-1,6-dien-4-yl)-4-methoxybenzene 
• 123-11-5 4-methoxy-benzaldehyde 
• 18648-74-3 2,2-diphenyl-1-(4-methoxyphenyl)ethylene 

Relevant academic research and scientific papers

Synthesis and pharmacological characterisation of arctigenin analogues as antagonists of AMPA and kainate receptors

(-)-Arctigenin and a series of new analogues have been synthesised and then tested for their potential as AMPA and kainate receptor antagonists of human homomeric GluA1 and GluK2 receptors expressed in HEK293 cells using a Ca2+ influx assay. In general, these compounds showed antagonist activity at both receptors with greater activity evident at AMPARs. Schild analysis indicates that a spirocyclic analogue 6c acts as a non-competitive antagonist. Molecular docking studies in which 6c was docked into the X-ray crystal structure of the GluA2 tetramer suggest that (-)-arctigenin and its analogues bind in the transmembrane domain in a similar manner to the known AMPA receptor non-competitive antagonists GYKI53655 and the antiepileptic drug perampanel. The arctigenin derivatives described herein may serve as novel leads for the development of drugs for the treatment of epilepsy. This journal is

Trithioorthoester Exchange and Metathesis: New Tools for Dynamic Covalent Chemistry

To expand the toolbox of dynamic covalent and systems chemistry, we investigated the acid-catalyzed exchange reaction of trithioorthoesters with thiols. We found that trithioorthoester exchange occurs readily in various solvents in the presence of stoichiometric amounts of strong Bronsted acids or catalytic amounts of certain Lewis acids. The scope of the exchange reaction was explored with various substrates, and conditions were identified that permit clean metathesis reactions between two different trithioorthoesters. One distinct advantage of S, S, S-orthoester exchange over O, O, O-orthoester exchange is that the exchange reaction can kinetically outcompete hydrolysis, thereby making the process less sensitive to residual moisture. We expect that the relatively high stability of the products might be beneficial in future supramolecular receptors or porous materials.

Visible-Light Photoredox-Catalyzed Thioacetalization of Aldehydes Under Metal-Free and Solvent-Free Conditions

A first visible-light photoredox-catalyzed thioacetalization of aldehydes under metal-free and solvent-free conditions is described. Under blue LED irradiation, a reactive thiyl radical was initially generated through single-electron oxidation of thiol, w

Thioacetalization of aldehydes and ketones catalyzed by hexabromoacetone

Protection of p-anisaldehydewith 1,3-propanedithiol under UV irradiation without a catalyst resulted in 87% yield of 1,3-dithiane in 20 min. Addition of hexabromoacetone further reduced the reaction time and UV irradiation also accelerated the formation o

Reduction of titanocene dichloride with dysprosium: Access to a stable titanocene(II) equivalent for phosphite-free Takeda carbonyl olefination

The reduction of titanocene dichloride with dysprosium yields a new titanocene(ii) equivalent without the need for further stabilising ligands. This reagent can be employed in combination with dithioacetals for the olefination of different carbonyl groups and allows for a simplified all-in-one procedure.

Rhodium-catalyzed denitrogenative thioacetalization of N-sulfonyl-1,2,3-triazoles with disulfides: An entry to diverse transformation of terminal alkynes

An efficient and useful rhodium-catalyzed denitrogenative thioacetalization of N-sulfonyl-1,2,3-triazoles has been developed for the first time. The protocol uses readily available N-sulfonyl-1,2,3-triazoles and diaryl disulfides as the starting materials. The corresponding hydrolytic and reductive products with thioacetals were obtained in good to excellent yields, and the reactions were carried out easily under mild conditions with tolerance of some functional groups. Furthermore, the generated thioacetals could be transformed into some useful compounds. Therefore, the present method provides a novel and valuable strategy for the diverse transformation of alkynes.

Graphene oxide (GO)-catalyzed chemoselective thioacetalization of aldehydes under solvent-free conditions

An efficient method for the synthesis of open chain, cyclic, and unsymmetrical dithioacetals from aryl/hetero-aryl/aliphatic aldehydes is described. The reaction is performed using graphene oxide (GO) as the catalyst under solvent-free and aerobic conditions. High chemoselectivity is observed in the reaction as aryl/alkyl ketones do not give thioketals under the condition.

Mesoporous silica-functionalized dual Br?nsted acidic ionic liquid as an efficient catalyst for thioacetalization of carbonyl compounds in water

A novel silica-functionalized dual Br?nsted acidic ionic liquid (ionic liquid with two Br?nsted acidic species) has been reported as a highly efficient catalyst for thioacetalization of carbonyl compounds. The reaction was efficiently performed in water a

Thioacetalization of aldehydes and ketones in SDS micelles

Aromatic aldehydes have been successfully converted into their corresponding dithioacetal, dithiolane and dithiane derivatives in excellent yields with thiol (benzyl thiol and thiophenol), 1,2-ethanedithiol and 1,3-propanedithiol using trichloroacetic acid in sodium dodecyl sulfate micelles. The same procedure is applicable to ketones, but they need more time to be converted into their thioacetals. Image Presented.

Cerium triflate: An efficient and recyclable catalyst for chemoselective thioacetalization of carbonyl compounds under solvent-free conditions

A simple and efficient chemoselective thioacetalization of carbonyl compounds has been achieved using Ce(OTf)3 (10 mol-%) as a catalyst under solvent-free conditions. Advantages of the methodology include very short reaction times, excellent yi