3-(1-cyano-1-methylethyl)-N-[3-({2-[(cyclopropylcarbonyl)amino]-7-(hydroxymethyl)-1,3-benzothiazol-6-yl}oxy)phenyl]benzamide

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Chemical Name:3-(1-cyano-1-methylethyl)-N-[3-({2-[(cyclopropylcarbonyl)amino]-7-(hydroxymethyl)-1,3-benzothiazol-6-yl}oxy)phenyl]benzamide
CAS No.:1228591-25-0
Molecular Formula:C₂₉H₂₆N₄O₄S
Molecular Weight:526.616
Hs Code.:

Synonyms:3-(1-cyano-1-methylethyl)-N-[3-({2-[(cyclopropylcarbonyl)amino]-7-(hydroxymethyl)-1,3-benzothiazol-6-yl}oxy)phenyl]benzamide

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Chemical Property of 3-(1-cyano-1-methylethyl)-N-[3-({2-[(cyclopropylcarbonyl)amino]-7-(hydroxymethyl)-1,3-benzothiazol-6-yl}oxy)phenyl]benzamide

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Technology Process of 3-(1-cyano-1-methylethyl)-N-[3-({2-[(cyclopropylcarbonyl)amino]-7-(hydroxymethyl)-1,3-benzothiazol-6-yl}oxy)phenyl]benzamide

There total 7 articles about 3-(1-cyano-1-methylethyl)-N-[3-({2-[(cyclopropylcarbonyl)amino]-7-(hydroxymethyl)-1,3-benzothiazol-6-yl}oxy)phenyl]benzamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 55.0%

: 1228591-24-9
6-[3-({[3-(1-cyano-1-methylethyl)phenyl]carbonyl}amino)phenoxy]-2-[(cyclopropylcarbonyl)amino]-1,3-benzothiazole-7-carboxylic acid

: 1228591-25-0
3-(1-cyano-1-methylethyl)-N-[3-({2-[(cyclopropylcarbonyl)amino]-7-(hydroxymethyl)-1,3-benzothiazol-6-yl}oxy)phenyl]benzamide

Guidance literature:: 6-[3-({[3-(1-cyano-1-methylethyl)phenyl]carbonyl}amino)phenoxy]-2-[(cyclopropylcarbonyl)amino]-1,3-benzothiazole-7-carboxylic acid; With triethylamine; isobutyl chloroformate; In tetrahydrofuran; for 0.5h;

With sodium tetrahydroborate; In tetrahydrofuran; methanol; at 20 ℃; for 2h;
DOI:10.1021/jm400778d

Reference yield:

: C₃₄H₃₂N₄O₇S

: 1228591-25-0
3-(1-cyano-1-methylethyl)-N-[3-({2-[(cyclopropylcarbonyl)amino]-7-(hydroxymethyl)-1,3-benzothiazol-6-yl}oxy)phenyl]benzamide

Guidance literature:: C₃₄H₃₂N₄O₇S; With sodium tetrahydroborate; In tetrahydrofuran; methanol; at 20 ℃; for 2h;

With hydrogenchloride; water; In ethyl acetate;

With sodium hydrogencarbonate; In water; ethyl acetate;

Reference yield:

: 1228591-22-7
methyl 5-amino-2-[3-({[3-(1-cyano-1-methylethyl)phenyl]carbonyl}amino)phenoxy]benzoate

: 1228591-25-0
3-(1-cyano-1-methylethyl)-N-[3-({2-[(cyclopropylcarbonyl)amino]-7-(hydroxymethyl)-1,3-benzothiazol-6-yl}oxy)phenyl]benzamide

Guidance literature:: Multi-step reaction with 4 steps

1.1: acetic acid / 0.17 h / 20 °C

1.2: 3 h / 20 °C

2.1: pyridine / 2 h / 20 °C

3.1: lithium hydroxide monohydrate / water; tetrahydrofuran; methanol / 12 h / 20 °C

4.1: triethylamine; isobutyl chloroformate / tetrahydrofuran / 0.5 h

4.2: 2 h / 20 °C

With pyridine; lithium hydroxide monohydrate; acetic acid; triethylamine; isobutyl chloroformate; In tetrahydrofuran; methanol; water;
DOI:10.1021/jm400778d